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Asian J Transfus Sci. 2019 Jul-Dec;13(2):90-94. doi: 10.4103/ajts.AJTS_16_19. Epub 2019 Dec 3.

Role of plasma exchange in postpartum microangiopathies: An experience from a tertiary care center.

Author information

1
Department of Transfusion Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
2
Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
3
Department of Obstetrics and Gyneacology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Abstract

BACKGROUND:

Postpartum microangiopathies are rare but are associated with high maternal and fetal mortality requiring early diagnosis and prompt treatment to improve the outcome.

AIMS AND OBJECTIVES:

This retrospective study aims to assess the efficacy of plasma exchange (PE) therapy in postpartum thrombotic microangiopathies.

MATERIALS AND METHODS:

We did retrospective analysis of all plasma exchange procedures performed in patients of postpartum thrombotic microangiopathies over a period of 1 year (2015-2016). Patient's pre- and post-plasma exchange hematological and biochemical parameters were recorded and compared for analyzing the response to the therapy. Patients were followed telephonically even after their discharge from the hospital.

RESULTS:

Hematological and renal profile improved in 8 out of 9 patients after PE therapy. Survival after PE therapy was 40% in post partum atypical HUS and 75% in patients with HELLP syndrome at 4 months of follow up.

CONCLUSION:

Early initiation of PE therapy in postpartum thrombotic microangiopathies can reduce morbidity and mortality associated with them.

KEYWORDS:

Microangiopathy; plasma exchange; postpartum

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