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Stem Cell Res. 2019 Dec 18;42:101692. doi: 10.1016/j.scr.2019.101692. [Epub ahead of print]

Generation of induced pluripotent stem cells MMCi001-A from a Taiwanese hearing loss patient carrying GJB2 pV37I mutation.

Author information

1
Bioresource Collection and Research Center, Food Industry Research and Development Institute, Hsinchu, Taiwan.
2
Institute of Biomedical Sciences, Mackay Medical College, New Taipei City, Taiwan.
3
Institute of Cellular and System Medicine, National Health Research Institutes, Miaoli, Taiwan.
4
Department of Audiology and Speech-Language Pathology, Mackay Medical College, New Taipei City, Taiwan; Department of Otolaryngology, Mackay Memorial Hospital, Taipei, Taiwan.
5
Institute of Biomedical Sciences, Mackay Medical College, New Taipei City, Taiwan. Electronic address: hsuyc@mmc.edu.tw.

Abstract

Hearing loss is the most common disorder in the sensory system. Mutations in GJB2 have been reported to be very common in sensorineural hearing loss patients. In this report, we generated an induced pluripotent stem cell (iPSC) line, MMCi001-A, from the peripheral blood mononuclear cells of a 4-year-old male hearing loss patient carrying GJB2 pV37I mutation by using the Sendai virus delivery system. The generated iPSCs were demonstrated to express pluripotent markers and be differentiated into three germ layers in vitro and in vivo. This GJB2-pV37I iPSCs is valuable for studying the pathogenic mechanisms and drug discovery of hearing loss.

PMID:
31896484
DOI:
10.1016/j.scr.2019.101692
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