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PLoS One. 2020 Jan 2;15(1):e0226546. doi: 10.1371/journal.pone.0226546. eCollection 2020.

Genetic predisposition to celiac disease in Kazakhstan: Potential impact on the clinical practice in Central Asia.

Author information

1
Department of Medicine, Nazarbayev University School of Medicine, Nur-Sultan City, Kazakhstan.
2
RSE on REM «Research and Production Center of Transfusion», Ministry of Health of the Republic of Kazakhstan, Nur-Sultan City, Kazakhstan.

Abstract

BACKGROUND:

Celiac disease (CD) is a systemic immune-mediated disorder developing in HLA genetically predisposed individuals carrying HLA-DQ2 and/or HLA-DQ8 molecules. Recent evidences supported a predominant importance of HLA-DQB1 locus and, in particular, HLA-DQB1*02 alleles. This diagnosis is poorly considered in Kazakhstan, because of the assumption that CD is not prevalent in this population.

OBJECTIVE:

To demonstrate that the genetic predisposition to CD in Kazakhstan is not negligible and is actually comparable to Western populations.

METHODS:

Through the analysis of HLA-DQ genotypes of healthy bone marrow donors from Kazakhstan's national registry, we estimated the HLA-related genetic predisposition to CD in the country.

RESULTS:

We demonstrated that the frequency of CD-related HLA-DQB1 alleles and, as a consequence, of predisposed individuals to CD in Kazakhstan is significant and comparable to countries with the highest disease prevalence.

CONCLUSION:

Considering the dietary style in Kazakhstan, including wheat as a staple food, these results provided a preliminary background of knowledge to expect a significant CD prevalence in Kazakhstan and Central Asia by implementing appropriate and cost-effective diagnostic strategies.

Conflict of interest statement

The authors have declared that no competing interests exist.

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