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Neuroimage Clin. 2019 Dec 14;25:102129. doi: 10.1016/j.nicl.2019.102129. [Epub ahead of print]

Task-related functional magnetic resonance imaging activations in patients with acute and subacute mild traumatic brain injury: A coordinate-based meta-analysis.

Author information

1
Priority Research Centre for Stroke and Brain Injury, University of Newcastle, Callaghan, NSW, Australia; School of Medicine and Public Health, University of Newcastle, Callaghan, NSW, Australia.
2
Priority Research Centre for Stroke and Brain Injury, University of Newcastle, Callaghan, NSW, Australia; School of Medicine and Public Health, University of Newcastle, Callaghan, NSW, Australia; Hunter New England Local Health District Sports Concussion Clinic, John Hunter Hospital, New Lambton Heights, NSW, Australia.
3
Department of Psychology, Faculty of Health, York University, Toronto, Ontario, Canada.
4
Centre for Clinical Neuropsychology Research, University of Exeter, Exeter, Devon, UK.
5
Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA, USA; Spaulding Rehabilitation Hospital, and Spaulding Research Institute, Charlestown, MA, USA; MassGeneral Hospital for Children™ Sports Concussion Program, Boston, MA, USA; Home Base, A Red Sox Foundation and Massachusetts General Hospital Home Base Program, Charlestown, MA, USA.
6
Priority Research Centre for Stroke and Brain Injury, University of Newcastle, Callaghan, NSW, Australia; School of Health Sciences, University of Newcastle, Callaghan, NSW, Australia. Electronic address: peter.stanwell@newcastle.edu.au.

Abstract

Task-based functional magnetic resonance imaging (fMRI) has been used to examine neuroanatomical and functional changes following mild traumatic brain injury (mTBI). Prior studies have lacked consistency in identifying common regions of altered neural activity during cognitive tasks. This may be partly due to differences in task paradigm, patient heterogeneity, and methods of fMRI analysis. We conducted a meta-analysis using an activation likelihood estimation (ALE) method to identify regions of differential brain activation in patients with mTBI compared to healthy controls. We included experiments that performed scans from acute to subacute time points post-injury. The seven included studies recruited a total sample of 174 patients with mTBIs and 139 control participants. The results of our coordinate based meta-analysis revealed a single cluster of reduced activation within the right middle frontal gyrus (MFG) that differentiated mTBI from healthy controls. We conclude that the cognitive impairments in memory and attention typically reported in mTBI patients may be associated with a deficit in the right MFG, which impacts the recruitment of neural networks important for attentional control.

KEYWORDS:

Activation likelihood estimation; Cognition; Concussion; Functional MRI; Mild traumatic brain injury; Neuroimaging

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