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Gene. 2020 Mar 1;729:144314. doi: 10.1016/j.gene.2019.144314. Epub 2019 Dec 26.

The genetic landscape of Arab Population, Chechens and Circassians subpopulations from Jordan through HV1 and HV2 regions of mtDNA.

Author information

1
Department of Applied Biological Sciences, Jordan University of Science and Technology, Irbid 22110, Jordan; Department of Biotechnology and Genetic Engineering, Jordan University of Science and Technology, Irbid 22110, Jordan. Electronic address: lneitan@just.edu.jo.
2
Computer Science Department, The University of Jordan, Amman 11942, Jordan.
3
Department of Applied Biological Sciences, Jordan University of Science and Technology, Irbid 22110, Jordan.
4
Department of Pharmacology, Faculty of Medicine, The University of Jordan, Amman 11942, Jordan.
5
Department of Biopharmaceutics and Clinical Pharmacy, School of Pharmacy, The University of Jordan, Amman 11942, Jordan.
6
Epigenetics Programme, The Babraham Institute, Cambridge, CB22 3AT, UK.
7
Epigenetics Programme, The Babraham Institute, Cambridge, CB22 3AT, UK; The Centre for Trophoblast Research, University of Cambridge, CB2 3EG, UK.
8
Department of Biology and Biotechnology, The Hashemite University, Zarqa 13133, Jordan; Radcliffe Institute for Advanced Studies, Harvard University, Cambridge, MA 02138, USA; Jepson School of Leadership, Richmond University, 221 Richmond Way, Richmond, VA 23173, USA.

Abstract

Mitochondrial DNA (mtDNA) is widely used in several fields including medical genetics, forensic science, genetic genealogy, and evolutionary anthropology. In this study, mtDNA haplotype diversity was determined for 293 unrelated subjects from Jordanian population (Circassians, Chechens, and the original inhabitants of Jordan). A total of 102 haplotypes were identified and analyzed among the populations to describe the maternal lineage landscape. Our results revealed that the distribution of mtDNA haplotype frequencies among the three populations showed disparity and significant differences when compared to each other. We also constructed mitochondrial haplotype classification trees for the three populations to determine the phylogenetic relationship of mtDNA haplotype variants, and we observed clear differences in the distribution of maternal genetic ancestries, especially between Arab and the minority ethnic populations. To our knowledge, this study is the first, to date, to characterize mitochondrial haplotypes and haplotype distributions in a population-based sample from the Jordanian population. It provides a powerful reference for future studies investigating the contribution of mtDNA variation to human health and disease and studying population history and evolution by comparing the mtDNA haplotypes to other populations.

KEYWORDS:

Arab; Chechens; Circassians; Jordan; Mitochondrial DNA; Phylogenetic

PMID:
31884104
DOI:
10.1016/j.gene.2019.144314

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