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Trends Parasitol. 2020 Feb;36(2):85-87. doi: 10.1016/j.pt.2019.12.006.

Targeting Plasmodium Plasmepsin V: Hitting Two Birds with One Stone.

Author information

1
Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland. Electronic address: nicolas.brancucci@swisstph.ch.
2
Institute of Cell Biology, University of Bern, Bern, Switzerland.
3
Institute of Cell Biology, University of Bern, Bern, Switzerland. Electronic address: christof.gruering@izb.unibe.ch.

Abstract

A recent report by Jennison et al. reveals an important role for plasmepsin V (PMV), an aspartyl protease, in the development of malaria transmission stages. The authors showed that PMV activity is critical for protein export in these stages and that specific PMV inhibitors block parasite transmission to mosquitoes.

KEYWORDS:

Anopheles mosquito; Plasmodium export element; aspartyl protease; gametocyte-exported proteins; malaria transmission; plasmepsin V

PMID:
31883707
DOI:
10.1016/j.pt.2019.12.006

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