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Liver Int. 2019 Dec 28. doi: 10.1111/liv.14344. [Epub ahead of print]

Hepatitis B virus activity is not associated with degree of liver steatosis in patients with hepatitis B-related chronic liver disease.

Author information

1
Department of Gastroenterology and Hepatology, Austin Health, Melbourne, Vic., Australia.

Abstract

BACKGROUND & AIMS:

The recently published manuscript by Zhu and colleagues "Hepatitis B virus infection and risk of non-alcoholic fatty liver disease: A population-based cohort study" found no correlation between presence of chronic HBV and presence of common risk factors for non-alcoholic fatty liver disease on primary analysis. A limitation to this study, like most population based research, is the absence of liver histology, which is considered gold standard for assessment of non-alcoholic fatty liver disease.

METHODS:

Our group studied the association between hepatitis B viral activity and non-alcoholic fatty liver disease activity as measured by grade of steatohepatitis/fibrosis on liver biopsy by analysing consecutive liver histology samples from patients with chronic hepatitis B at a single quaternary liver transplant centre.

RESULTS:

Linear regression modelling for active viral hepatitis on histological examination against degree of steatohepatitis showed no correlation (r2  = .018, all P> .1). Linear regression of degree of steatohepatitis vs hepatitis B viral load also showed no correlation.

CONCLUSIONS:

Our work is concordant with the manuscript from Zhu et al; we found no significant correlation between hepatitis B viral activity and degree of steatohepatitis.

KEYWORDS:

fatty liver; hepatitis B; non-alcoholic fatty liver disease

PMID:
31883410
DOI:
10.1111/liv.14344

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