Reshaping Chromatin Architecture around DNA Breaks

Pierre Caron; Sophie E Polo

doi:10.1016/j.tibs.2019.12.001

Reshaping Chromatin Architecture around DNA Breaks

Trends Biochem Sci. 2020 Mar;45(3):177-179. doi: 10.1016/j.tibs.2019.12.001. Epub 2019 Dec 24.

Authors

Pierre Caron¹, Sophie E Polo²

Affiliations

¹ Epigenetics and Cell Fate Centre, UMR7216 CNRS, Université de Paris, F-75013, Paris, France.
² Epigenetics and Cell Fate Centre, UMR7216 CNRS, Université de Paris, F-75013, Paris, France. Electronic address: sophie.polo@univ-paris-diderot.fr.

PMID: 31882194
DOI: 10.1016/j.tibs.2019.12.001

Abstract

DNA double-strand breaks (DSBs) elicit major chromatin changes. Using super-resolution microscopy in human cells, Ochs et al. unveil that the DSB response protein 53BP1 and its effector RIF1 organize DSB-flanking chromatin into circular micro-domains. These structures control the spatial distribution of DSB repair factors safeguarding genome integrity.

Keywords: 53BP1; DNA double-strand break repair; RIF1; chromatin topology; cohesins; super-resolution microscopy.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Chromatin*
DNA Breaks, Double-Stranded
DNA Repair*
Humans

Substances

Chromatin