Format

Send to

Choose Destination
J Neurotrauma. 2019 Dec 27. doi: 10.1089/neu.2018.6083. [Epub ahead of print]

Interleukin-8 Predicts Fatigue at 12 Months Post-injury in Children with Traumatic Brain Injury.

Author information

1
Murdoch Childrens Research Institute, 34361, Clinical Sciences, Parkville, Victoria, Australia.
2
Monash University Faculty of Medicine Nursing and Health Sciences, 22457, School of Clinical Sciences, Department of Paediatrics, Clayton, Victoria, Australia; ali.crichton@monash.edu.
3
Murdoch Childrens Research Institute, 34361, Haematology Research, Clinical Sciences, Parkville, Victoria, Australia.
4
University of Melbourne, Department of Paediatrics, Parkville, Victoria, Australia; vera.ignjatovic@mcri.edu.au.
5
Royal Childrens Hospital, Emergency, Melbourne, Victoria, Australia.
6
University of Melbourne, Department of Paediatrics, Parkville, Victoria, Australia.
7
Murdoch Childrens Research Institute, 34361, Parkville, Victoria, Australia; franz.babl@rch.org.au.
8
Royal Children's Hospital Melbourne, 6453, Emergency Medicine, Parkville, Victoria, Australia; edward.oakley@mcri.edu.au.
9
Murdoch Childrens Research Institute, 34361, Parkville, Victoria, Australia.
10
University of Melbourne, School of Psychological Sciences, Parkville, Victoria, Australia; mardee.greenham@mcri.edu.au.
11
Murdoch Childrens Research Institute, Flemington Road, Parkville, Victoria, Australia, 3052; stephen.hearps@mcri.edu.au.
12
Royal Children's Hospital Melbourne, 6453, Pediatric Intensive Care Unit, Parkville, Victoria, Australia.
13
Murdoch Childrens Research Institute, Parkville, Victoria, Australia; carmel.delzoppo@rch.org.au.
14
University of Montreal, Department of Psychology, Montreal, Quebec, Canada.
15
Ste-Justine Hospital, Research Center, Montreal, Quebec, Canada; miriam.beauchamp@umontreal.ca.
16
Hospital for Sick Children, Critical Care Medicine, Toronto, Ontario, Canada.
17
The Hospital for Sick Children Research Institute, Neuroscience and Mental Health Research Program, Toronto, Ontario, Canada; anne-marie.guerguerian@sickkids.ca.
18
Hospital for Sick Children, Pediatric Emergency Medicine, Toronto, Ontario, Canada.
19
University of Toronto, The Interdepartmental Division of Critical Care, Toronto, Ontario, Canada; kathy.boutis@sickkids.ca.
20
SickKids, 7979, Critical Care Medicine, Toronto, Ontario, Canada; evyatarhu@gmail.com.
21
University of Toronto, The Interdepartmental Division of Critical Care, Toronto, Ontario, Canada.
22
The Hospital for Sick Children Research Institute, Neuroscience and Mental Health Research Program, Toronto, Ontario, Canada; jamie.hutchison@sickkids.ca.
23
Royal Children's Hospital Melbourne, 6453, Parkville, Victoria, Australia.
24
University of Melbourne, School of psychological Sciences, Parkville, Victoria, Australia; vicki.anderson@rch.org.au.

Abstract

Despite many children experiencing fatigue after childhood brain injury, little is known about the predictors of this complaint. To date, traditional indices of traumatic brain injury (TBI) severity have not reliably predicted persisting fatigue (up to 3 years post-injury). This study aimed to establish if persisting fatigue is predicted by serum biomarker concentrations in child TBI. We examined if acute serum biomarker expression would improve prediction models of 12-month fatigue based on injury severity. Blood samples were collected from 87 children (1 - 17 years at injury) sustaining mild to severe TBI (GCS range 3-15; mean 12.43; classified as mild TBI (n=50, 57%) vs moderate/severe TBI n=37, 43%), and presenting to the Emergency Departments (ED) and Pediatric Intensive Care Units (PICU) at one of three tertiary pediatric hospitals (Royal Children's Hospital (RCH); Hospital for Sick Children (HSC), Toronto St Justine Children's Hospital (SJH), Montreal). Six serum biomarker concentrations were measured within 24 hours of injury [interleukin-6 (IL-6), interleukin-8 (IL-8), soluble vascular cell adhesion molecule (SVCAM), S100 calcium binding protein B (S100B), neuron specific enolase (NSE), and soluble neural cell adhesion molecule (sNCAM)]. Fatigue at 12 months post-injury was measured using the Pediatric Quality of Life Inventory Multidimensional Fatigue Scale (parent report), classified as present/absent using previously derived cut-points. At 12 months post-injury, 22% of participants experienced fatigue. A model including interleukin-8 (IL-8) was the best serum biomarker for estimating the probability of children experiencing fatigue at 12 months post-injury. IL-8 also significantly improved predictive models of fatigue based on severity.

KEYWORDS:

BIOMARKERS; PEDIATRIC BRAIN INJURY; RECOVERY; TRAUMATIC BRAIN INJURY

PMID:
31880977
DOI:
10.1089/neu.2018.6083

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center