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Biofactors. 2019 Dec 27. doi: 10.1002/biof.1605. [Epub ahead of print]

Quercetin: A promising phytochemical for the treatment of glioblastoma multiforme.

Author information

1
Student Research Committee, Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran.
2
Department of Physiology and Pharmacology, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran.
3
Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran.
4
College of Pharmacy, University of Rhode Island, Kingston, CA.
5
Department of Medical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
6
Halal Research Center of IRI, FDA, Tehran, Iran.
7
Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
8
Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract

Quercetin, a plant-derived flavonoid, is known for its antitumor and antiproliferative activities. Glioblastoma multiforme (GBM), as a highly aggressive cerebrum tumor, has a poor prognosis that is approximately 12 months despite standard therapy. Therefore, because of the low effectiveness of the current therapeutic strategies, additional medications in combination with chemotherapy and radiotherapy are needed, which could improve the prognosis of GBM patients. Multiple lines of evidence have shown that quercetin regulates many proteins involved in the cellular signal transduction in GBM. In this review, recent findings on the targeting of particular signaling pathways by quercetin and the subsequent effect on the pathogenesis of GBM are presented and discussed.

KEYWORDS:

antitumor; flavonoid; glioblastoma multiforme; quercetin; signal transduction

PMID:
31880372
DOI:
10.1002/biof.1605

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