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Prion. 2020 Dec;14(1):20-23. doi: 10.1080/19336896.2019.1704496.

Cloning and analysis of PRNP gene of Vulpes corsac in Qinghai plateau, China.

Author information

1
State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases (Zhejiang University), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.
2
Center for Global Public Health, Chinese Center for Disease Control and Prevention, Beijing, China.
3
Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, People's Republic of China.

Abstract

PRNP gene encodes PrP protein, which is conservative among different species and associates with the susceptibility of prion disease. In this report, we cloned and sequenced the full-length PRNP gene of Vulpes corsac in Qinghai plateau, China. The amino acid sequence of Vulpes corsac PrP showed 100% homology with those of the other three species of foxes. The taxa relationship of Vulpes corsac PrP with other species of animals, including human, canine, bovine, cervus, capra, ovis, camelus, felis, Mustela, mouse and hamster were also analysed.

KEYWORDS:

PRNP; Qinghai plateau; Vulpes corsac; prion disease

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