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J Asthma. 2020 Jan 10:1-14. doi: 10.1080/02770903.2019.1709866. [Epub ahead of print]

Effect of omega-3 fatty acids supplementation during childhood in preventing allergic disease: a systematic review and Meta-Analysis.

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Department of Respiratory Disease; Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders; China International Science and Technology Cooperation Base of Child Development and Critical Disorders; Chongqing Key Laboratory of Pediatrics, Children's Hospital of Chongqing Medical University, Chongqing, P.R China.


Background: Early omega-3 fatty acids exposure can influence early immune development and potentially prevent allergic disease.Objectives: To review the effects of omega-3 fatty acids during childhood on allergic disease outcomes.Methods: We conducted searches of the PubMed, EMBASE and Cochrane Central Register of Controlled Trials and international trial registers ( and ISRCTN Registry) to September 30, 2018. We included randomized controlled trials (RCTs) and prospective cohort studies regarding the effect of omega-3 fatty acids during childhood on allergic disease outcomes. A total of 8 publications from 2 prospective cohort studies and 6 reports representing 5 unique RCTs were included.Results: The results of meta-analysis showed that omega-3 fatty acids during childhood did not appear to significantly alter the risk of any atopy (≤3 years old: RR 0.70, 95% CI 0.47 to 1.04, p = 0.08; > 3 years old: RR 0.98, 95% CI 0.82 to 1.16, p = 0.77), wheeze (≤3 years old: RR 0.82, 95% CI 0.54 to 1.26, p = 0.375; > 3 years old: RR 1.03, 95% CI 0.53 to 2.00, p = 0.929) and eczema (≤3 years old: RR 0.86, 95% CI 0.68 to 1.08, p = 0.20; > 3 years old: RR 0.90, 95% CI 0.60 to 1.35, p = 0.60).Conclusions: There is limited evidence to support omega-3 fatty acids during childhood could reduce the risk of allergic disease.


Omega-3 fatty acids; allergic disease; asthma; eczema; meta-analysis; wheeze

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