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Ind Psychiatry J. 2019 Jan-Jun;28(1):152-154. doi: 10.4103/ipj.ipj_8_19. Epub 2019 Dec 11.

Risperidone-induced retrograde ejaculation and lurasidone may be the alternative.

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Department of Psychiatry, Sri Ramachandra Medical College and Research Institute, SRIHER, Chennai, Tamil Nadu, India.


Medication adherence with antipsychotics is adversely impacted by the burden of untoward adverse effects. In particular, sexual side effects are often underreported by patients, which may interfere with drug compliance. Presented here is the case of a 35-year-old male with schizophrenia, previously treated with risperidone following which he developed sexual dysfunction and hence was stopped. He was admitted to our psychiatric inpatient ward after a second psychotic exacerbation of the disorder after being drug free for about 6 months. On admission, treatment with risperidone was restarted, following which he developed retrograde ejaculation on oral risperidone therapy at a dose of 8 mg/day, with resolution of symptoms after cross tapering risperidone with lurasidone. Pharmacological interventions that may reduce antipsychotic-induced sexual dysfunction include changing the type of medication and administering other medications that are known to improve sexual dysfunction. This case emphasizes the need for routine inquiry into sexual dysfunction during atypical antipsychotic therapy.


Antipsychotic; lurasidone; retrograde ejaculation; risperidone; sexual dysfunction

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