Objective: This study aimed to investigate the value of normalized iodine concentration (NIC), spectral attenuation curve slope (SACS), area under curve (AUC), and iodine concentration difference (ICD) generated from spectral CT in the assessment of parotid gland tumors.
Methods: Ninety-two patients with pathologically confirmed parotid gland tumors underwent arterial phase- and venous phase-enhanced CT in spectral CT. The patients were divided into the pleomor-phic adenoma group (group A), Warthin tumor group (group B), basal cell tumor group (group C), and malignant tumor group (group D). The SACS, AUC, NIC, ICD were measured and analyzed. Statistical analyses were performed by one-way ANOVA, and statistical significance was set at P<0.05.
Results: SACS(AP), AUC(AP), and NIC(AP) in group A were lower than those in other groups; SACS(VP) and AUC(VP) in group C were higher than those in other groups; NIC(AP) and NIC(VP) in group D were higher than those in other groups; and ICD in group B was a positive number. The difference in SACS(AP) and AUC(AP) in groups B and C, SACS(VP) and AUC(VP) in groups C and D, and ICD in groups A and C were not statistically significant. By contrast, the diffe-rence between the other groups was statistically significant (P<0.05). The difference in NIC(AP) between groups A and B and groups C and D and the difference in NIC(VP) between groups A and C, groups A and D, and groups B and C were statistically significant (P=0.005, 0.025, 0.002, 0.038, and 0.049, respectively).
Conclusions: Multi-quantitative parameters from spectral CT might be helpful in differentiating various types of parotid gland tumors.
目的 通过对腮腺肿瘤的能谱曲线斜率（SACS）、曲线下面积（AUC）、标准化碘基值（NIC）、碘浓度差（ICD）的比较，分析能谱定量参数值在腮腺肿瘤定性诊断中的应用价值。方法 应用能谱CT对92例腮腺肿瘤患者进行动脉期（AP）、静脉期（VP）增强扫描。依据病理结果分为多形性腺瘤组（A组）、沃辛瘤组（B组）、基底细胞腺瘤组（C组）、恶性肿瘤组（D组）。测量并计算双期扫描中肿瘤的SACS、AUC、NIC及ICD。多组定量资料比较采用单因素方差分析，P<0.05为差异具有统计学意义。结果 A组SACS(AP)、AUC(AP)及NIC(AP)均低于其余各组，C组SACS(VP)、AUC(VP)均高于其余各组，D组NIC(AP)、NIC(VP)高于其他各组，B组ICD差值为正值。除B组和C组间SACS(AP)、AUC(AP)的差异以及C组和D组间SACS(VP)、AUC(VP)的差异以及A组和C组间ICD的差异无统计学意义外，其余各组之间的差异均具有统计学意义（P<0.05）。A组和B组、C组和D组间NIC(AP)的差异以及A组和C组、A组和D组、B组和C组NIC(VP)的差异具有统计学意义（P=0.005、0.025、0.002、0.038、0.049）。结论 不同病理类型的腮腺肿瘤能谱CT定量参数值存在差异，利用能谱CT多参数成像有助于腮腺肿瘤的定性诊断。.
Keywords: iodine concentration; parotid gland tumor; spectral imaging; tomography.