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Chem Biol Interact. 2019 Dec 19:108930. doi: 10.1016/j.cbi.2019.108930. [Epub ahead of print]

Functional role of ferroptosis on cancers, activation and deactivation by various therapeutic candidates-an update.

Author information

1
Institute of Research and Development, Duy Tan University, Da Nang, 550000, Viet Nam.
2
College of Rehabilitation, Shandong University of Traditional Chinese Medicine, Shandong, China.
3
Department of Physical Therapy, Asia University, Taichung, Taiwan; Department of Physical Therapy Graduate Institute of Rehabilitation Science, China Medical University, Taichung, Taiwan.
4
Department of Biotechnology, Asia University, Taichung, Taiwan. Electronic address: bharathvel@asia.edu.tw.

Abstract

Ferroptosis is recently identified form of regulated cell death which differs from previously identified cell death in a way that it is driven by iron-dependent lipid peroxide accumulation. Morphologically, cell volume shrinkage and increased mitochondrial membrane density are main features which characterize this form of cell death. Molecular mechanism of ferroptosis induction involved suppression of the phospholipid glutathione peroxidase 4 (GPX4) and further intracellular accumulation of lipid reactive oxygen species (ROS), a process in which iron is involved; either via inhibition of system Xc- (cystine/glutamate antiporter) or direct inhibition of GPX4. Several other pathways like RAS/MAPK and NRF2 are found to be involved in ferroptosis regulation. However, the precise mechanism of ferroptosis induction is not revealed till date. Like other regulated cell deaths, ferroptosis plays important role in tumor suppression and progression as revealed by several scientific reports. This review summarizes basic information about discovery of this novel cell death mechanism including molecular mechanism of its induction and further explain the roles of ferroptosis in human cancers.

KEYWORDS:

Cell death; Ferroptosis; GPX4; Human cancers; ROS

PMID:
31866335
DOI:
10.1016/j.cbi.2019.108930

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