Send to

Choose Destination
J Int Soc Sports Nutr. 2019 Dec 21;16(1):62. doi: 10.1186/s12970-019-0329-0.

International Society of Sports Nutrition Position Stand: Probiotics.

Author information

Increnovo LLC, Milwaukee, WI, USA.
College of Health Solutions, Arizona State University, Phoenix, AZ, USA.
Isagenix International LLC, Gilbert, AZ, USA.
Exercise and Performance Nutrition Laboratory, School of Health Sciences, Lindenwood University, St. Charles, MO, USA.
Increnovo LLC, Milwaukee, WI, USA.
University of Münster, Department of Physics Education, Münster, Germany.
Exercise and Nutrition Science Graduate Program, Lipscomb University, Nashville, TN, USA.
Otto Loewi Research Center, Medical University of Graz, Graz, Austria.
School of Medical Science and Menzies Health Institute of QLD, Griffith Health, Griffith University, Southport, Australia.
Department of Human Nutrition, University of Otago, Dunedin, New Zealand.
School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.
Research Institute for Sport and Exercise, University of Canberra, Canberra, ACT, 2617, Australia.
WGI, Lewisville, TX, USA.
UofSC Sport Science Lab, Department of Exercise Science, University of South Carolina, Columbia, SC, USA.
Applied Physiology Laboratory, Department of Exercise and Sport Science, University of North Carolina, Chapel Hill, NC, USA.
Exercise & Sport Nutrition Lab, Human Clinical Research Facility, Department of Health & Kinesiology, Texas A&M University, College Station, TX, USA.
Performance & Physique Enhancement Laboratory, University of South Florida, Tampa, FL, USA.
Institute of Performance Nutrition, London, UK.
Fitbiomics, Inc, New York, NY, USA.
Jamieson Wellness Inc, Windsor, Ontario, Canada.
Bioloab Research, Novara, Italy.
Scientific Affairs. Nutrasource Diagnostics, Inc. Guelph, Guelph, Ontario, Canada.
Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Tom Reilly Building, Byrom St Campus, Liverpool, UK.
International Probiotic Association, Los Angeles, CA, USA.
Exercise and Sport Science, Nova Southeastern University, Davie, FL, USA.


Position statement: The International Society of Sports Nutrition (ISSN) provides an objective and critical review of the mechanisms and use of probiotic supplementation to optimize the health, performance, and recovery of athletes. Based on the current available literature, the conclusions of the ISSN are as follows: 1)Probiotics are live microorganisms that, when administered in adequate amounts, confer a health benefit on the host (FAO/WHO).2)Probiotic administration has been linked to a multitude of health benefits, with gut and immune health being the most researched applications.3)Despite the existence of shared, core mechanisms for probiotic function, health benefits of probiotics are strain- and dose-dependent.4)Athletes have varying gut microbiota compositions that appear to reflect the activity level of the host in comparison to sedentary people, with the differences linked primarily to the volume of exercise and amount of protein consumption. Whether differences in gut microbiota composition affect probiotic efficacy is unknown.5)The main function of the gut is to digest food and absorb nutrients. In athletic populations, certain probiotics strains can increase absorption of key nutrients such as amino acids from protein, and affect the pharmacology and physiological properties of multiple food components.6)Immune depression in athletes worsens with excessive training load, psychological stress, disturbed sleep, and environmental extremes, all of which can contribute to an increased risk of respiratory tract infections. In certain situations, including exposure to crowds, foreign travel and poor hygiene at home, and training or competition venues, athletes' exposure to pathogens may be elevated leading to increased rates of infections. Approximately 70% of the immune system is located in the gut and probiotic supplementation has been shown to promote a healthy immune response. In an athletic population, specific probiotic strains can reduce the number of episodes, severity and duration of upper respiratory tract infections.7)Intense, prolonged exercise, especially in the heat, has been shown to increase gut permeability which potentially can result in systemic toxemia. Specific probiotic strains can improve the integrity of the gut-barrier function in athletes.8)Administration of selected anti-inflammatory probiotic strains have been linked to improved recovery from muscle-damaging exercise.9)The minimal effective dose and method of administration (potency per serving, single vs. split dose, delivery form) of a specific probiotic strain depends on validation studies for this particular strain. Products that contain probiotics must include the genus, species, and strain of each live microorganism on its label as well as the total estimated quantity of each probiotic strain at the end of the product's shelf life, as measured by colony forming units (CFU) or live cells.10)Preclinical and early human research has shown potential probiotic benefits relevant to an athletic population that include improved body composition and lean body mass, normalizing age-related declines in testosterone levels, reductions in cortisol levels indicating improved responses to a physical or mental stressor, reduction of exercise-induced lactate, and increased neurotransmitter synthesis, cognition and mood. However, these potential benefits require validation in more rigorous human studies and in an athletic population.


Gut-muscle-Axis; Microbiome; Microbiota; Muscle; Sport performance

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center