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Brain Sci. 2019 Dec 17;9(12). pii: E382. doi: 10.3390/brainsci9120382.

Reports of L-Norvaline Toxicity in Humans May Be Greatly Overstated.

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Drug Discovery Laboratory, The Azrieli Faculty of Medicine, Bar-Ilan University, Safed 1311502, Israel.
Scientific Research Institute of Physiology and Basic Medicine, 4 Timakova St., Novosibirsk 630117, Russia.


Recently, a study published in "Toxicology In Vitro" (Kate Samardzic and Kenneth J. Rodgers) was entitled: "Cytotoxicity and Mitochondrial Dysfunction Caused by the Dietary Supplement L-Norvaline". The title may be greatly overstated, and here we provide several arguments showing that norvaline is not as toxic as reported.


L-norvaline; brain; supplement; toxicity

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