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Med Sci (Paris). 2019 Nov;35 Hors série n° 2:18-23. doi: 10.1051/medsci/2019178. Epub 2019 Dec 20.

[Dermatomyositis: new antibody, new classification].

[Article in French; Abstract available in French from the publisher]

Author information

Service de Rhumatologie Maison Blanche, CHU de Reims, Reims, France.
Centre de référence des pathologies neuromusculaires Paris Nord Est, service de neurophysiologie clinique, Hôpital universitaire Necker Enfants Malades, APHP.5, Université de Paris, France.
Service de médecine interne et immunologie clinique, APHP Pitié-Salpêtrière, Paris, France.


in English, French

Dermatomyositis are rare chronic auto-immune diseases characterized by cutaneous involvement. Diagnosis could be made in childhood or in aldult. There are some different clinical and histological presentation associated with different myositis specific antibody. There are five dermatomyositis specific autoantibodies, anti-Mi2, anti-Tif1-γ, anti-NXP2, anti-MDA5, and anti-SAE. Anti-Mi2 are associated with "classical form" of DM with cutaneous and muscular involvement. Anti-Tif1γ and anti-NXP2 are found in juvenile and adult dermatomyositis, and are associated with recurrent diseases with cutaneous involvement at the forefront. In adults, they are associated with cancer. Anti-MDA5 antibodies are associated with a systemic involvement and an interstitial lung disease. Finally, anti-SAE have been found only in adults, with a classic form.


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