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Neurol India. 2019 Nov-Dec;67(6):1469-1471. doi: 10.4103/0028-3886.273638.

Differential DNA Methylation Patterns in Patients with Epilepsy due to Malformations of Cortical Development: A Pilot Study.

Author information

1
Division of Neurogenetics and Developmental Pediatrics, Children's National Hospital, Washington, DC, USA.
2
Division of Genetic, Genomic and Metabolic Disorders, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI, USA.

Abstract

Objective:

To study the DNA methylation profiles in brain tissue of patients with refractory epilepsy due to malformations of cortical development (MCDs).

Materials and Methods:

Clinical, neuroimaging, and pathology characteristics were defined for 13 patients who underwent resective surgery for epilepsy. Methylation analysis was performed using Illumina® 450k Methylation Microarray. Data analysis was completed, and pathway identification was done using the R/Bioconductor package.

Results:

Genes associated with Ephrin-Reelin pathway, potassium channels, and glutathione metabolism were differentially methylated in the MCD group when compared with patients who had no evidence of MCD.

Conclusions:

Our preliminary data reveal that epigenetic pathways may have a role in the pathobiogenesis of MCDs.

KEYWORDS:

DNA methylation; malformations of cortical development; neurogenetics; refractory epilepsy

PMID:
31857537
DOI:
10.4103/0028-3886.273638
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