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Neurol India. 2019 Nov-Dec;67(6):1439-1445. doi: 10.4103/0028-3886.273632.

The Predictive Value of Conventional Magnetic Resonance Imaging Sequences on Operative Findings and Histopathology of Intracranial Meningiomas: A Prospective Study.

Author information

1
Department of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
2
Department of Radiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
3
Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Abstract

Background:

Previous studies have tried to relate magnetic resonance (MR) characteristics of meningiomas with its intraoperative features and histopathology with varying results. This is a prospective study to assess the independent predictive value of conventional MR signals [T1, T2, and fluid attenuated inversion recovery (FLAIR)] in relation to consistency, vascularity, operative plane, Simpson excision, and histopathology of intracranial meningiomas in a multivariate model.

Materials and Methods:

Seventy patients underwent T1, T2, FLAIR, postcontrast sequences followed by excision of their meningiomas. Tumor signal intensity in various sequences was studied in relation to the above-mentioned variables. Multivariate analysis to find their independent association was performed.

Results:

T1 images showed no correlation with any of the variables. FLAIR hypointensity and inhomogeneous enhancement had significant association with tumor hardness. FLAIR hypointense tumors were associated with low vascularity. FLAIR hypointensity, skull base location, and recurrence were significantly related to the subpial or mixed operative plane. The meningioma-brain interface on T2 sequence was significantly related to the operative plane. Only skull base location had significant impact on the extent of excision. T2 and FLAIR hypointensity had significant association with fibroblastic or psammomatous meningiomas. On multivariate analysis, FLAIR hypointensity and skull base location had a significant independent relationship with suboptimal operative plane, while skull base location had association with the extent of excision. Among MRI sequences, FLAIR hypointensity showed high specificity (94%) in predicting the suboptimal operative plane.

Conclusions:

FLAIR hypointensity of meningiomas appears to have a significant independent association with the suboptimal operative plane with high specificity.

KEYWORDS:

Fluid attenuated inversion recovery; histopathology; magnetic resonance imaging; meningioma; meningioma–brain interface; operative plane

PMID:
31857531
DOI:
10.4103/0028-3886.273632
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