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Indian J Dermatol Venereol Leprol. 2019 Dec 17. doi: 10.4103/ijdvl.IJDVL_1011_18. [Epub ahead of print]

Thymocyte selection-associated high-mobility group box as a potential diagnostic marker differentiating hypopigmented mycosis fungoides from early vitiligo: A pilot study.

Author information

1
Department of Dermatology and Venereology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Abstract

Background:

Hypopigmented mycosis fungoides is a rare variant of mycosis fungoides that may mimic many benign inflammatory hypopigmented dermatoses, and as yet there is no identified marker to differentiate between them.

Aim:

The aim of this study was to study the expression of thymocyte selection-associated high-mobility group box (TOX) in hypopigmented mycosis fungoides and one of its inflammatory mimickers (early active vitiligo) to assess its potential as a differentiating diagnostic marker.

Methods:

A case-control study was done using immunohistochemical analysis of TOX expression in 15 patients with hypopigmented mycosis fungoides and 15 patients with early active vitiligo. Immunohistochemical analysis was done via a semi-quantitative method and an image analysis method.

Results:

Hypopigmented mycosis fungoides showed a statistically significant higher expression of TOX than early active vitiligo. The expression of TOX was positive in a majority of hypopigmented mycosis fungoides cases (14 cases, 93.3%), while only one case (6.7%) of vitiligo was weakly positive. TOX also displayed 93.3% sensitivity and specificity, with a cut-off value of 1.5.

Limitations:

This was a pilot study testing hypopigmented mycosis fungoides against only a single benign inflammatory mimicker (early vitiligo). Other benign mimickers were not included.

Conclusion:

Our findings showed that TOX expression can differentiate hypopigmented mycosis fungoides from early active vitiligo which is one of its benign inflammatory mimickers, with a high degree of sensitivity and specificity.

KEYWORDS:

Cutaneous T-cell lymphoma; TOX; hypopigmented mycosis fungoides; oncogenesis; thymocyte selection–associated high-mobility group box; vitiligo

PMID:
31857520
DOI:
10.4103/ijdvl.IJDVL_1011_18
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