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Nature. 1988 Nov 3;336(6194):42-8.

A peptide model of a protein folding intermediate.

Author information

1
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Massachusetts 02142.

Abstract

It is difficult to determine the structures of protein folding intermediates because folding is a highly cooperative process. A disulphide-bonded peptide pair, designed to mimic the first crucial intermediate in the folding of bovine pancreatic trypsin inhibitor, contains secondary and tertiary structure similar to that found in the native protein. Peptide models like this circumvent the problem of cooperativity and permit characterization of structures of folding intermediates.

PMID:
3185721
DOI:
10.1038/336042a0
[Indexed for MEDLINE]

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