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Indian J Ophthalmol. 2020 Jan;68(1):224-226. doi: 10.4103/ijo.IJO_475_19.

Severe focal stromal degeneration up to Descemet membrane after corneal collagen cross-linking.

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Department of Cornea and Refractive Surgery, Sankara Eye Hospital, Coimbatore, Tamil Nadu, India.


Corneal collagen cross-linking (CXL) is an effective treatment for arresting progression in keratoconus cases. It is considered safe despite a few complications that have been recorded earlier. In this case series, we report a rare and late complication caused due to severe stromal thinning up to Descemet's membrane in three patients who underwent CXL 3 to 6 years back for keratoconus. Deep anterior lamellar keratoplasty (DALK) was then done for the affected eye with good outcomes. This case series highlights the possible late effects of UVA irradiation post CXL.


Collagen cross-linking; descemetocele; keratoconus; stromal thinning; ultraviolet A irradiation

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