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Indian J Ophthalmol. 2020 Jan;68(1):15-22. doi: 10.4103/ijo.IJO_760_19.

Association between serum 25-hydroxyvitamin D levels and myopia in general Korean adults.

Author information

1
Department of Ophthalmology, Apgujung St. Mary's Eye Center, Seoul, Korea.
2
Department of Ophthalmology and Visual Science, St. Vincent's Hospital College of Medicine, Catholic University of Korea, Suwon, Korea.

Abstract

Purpose:

We performed this study to determine the association between serum 25-hydroxyvitamin D [25(OH) D] level and myopia in adults.

Methods:

A total of 25,199 subjects aged ≥20 years were included from the National Health and Nutrition Examination Survey 2008-2012. Blood 25(OH)D levels were evaluated from blood samples. Refractive error was measured without cycloplegia. Myopia and high myopia were defined as ≥-0.50 diopters (D) and ≥-6.0 D, respectively. Other covariates such as education, physical activity, and economic status were obtained from interviews.

Results:

Linear regression analysis showed that as 25(OH) D level increased by 1 ng/mL, myopic refractive error significantly decreased by 0.01 D (P < 0.001) after adjusting for potential confounders including sex, age, height, education level, economic status, physical activity, and sunlight exposure time. The odds ratios for myopia was 0.75 (95% Confidence interval [CI]; 0.67-0.84, P < 0.001) in the highest 25(OH) D quintile compared to the lowest quintile. The odds ratios for high myopia was 0.63 (95% CI; 0.47-0.85, P < 0.001) in the highest 25(OH)D quintile compared to the lowest quintile.

Conclusion:

: Serum 25(OH)D level was inversely associated with myopia in Korean adults.

KEYWORDS:

25-hydroxyvitamin D; Korean; adults; high myopia; myopia

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