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Curr Mol Med. 2019 Dec 18. doi: 10.2174/1566524020666191219102746. [Epub ahead of print]

Depression as is seen by molecular spectroscopy. Phospholipid-protein balance in affective disorders and dementia.

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College of Natural Sciences, University of Rzeszow, Rzeszow, and the Institute of Nuclear Chemistry and Technology, Warsaw. Poland.
College of Natural Sciences, University of Rzeszow, Rzeszow. Poland.


There is an expanding field of research investigating the instrumental methods to measure development of affective disorders. The goal of the commentary is to turn attention of medical practitioners at the molecular spectroscopy techniques (FTIR, Raman and UV-Vis) that can be applied for monitoring and quantification of the phospholipid-protein balance in human blood serum of depressed patients. Even facial overview of cited original research strongly suggest that disturbed phospholipid-protein balance could be one of the biomarkers of affective disorders. The blood serum monitoring of depressed patients would serve as a tool for more effective holistic therapy.


Affective disorders; biomarkers; bipolar disorder; dementia; major depression; phospholipid-protein balance; vibrationa spectroscopy

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