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PLoS One. 2019 Dec 18;14(12):e0226679. doi: 10.1371/journal.pone.0226679. eCollection 2019.

Early neonatal outcomes of very-low-birth-weight infants in Turkey: A prospective multicenter study of the Turkish Neonatal Society.

Author information

1
Department of Neonatology, Gazi University Faculty of Medicine, Ankara,Turkey.
2
Department of Neonatology, Yildirim Beyazit University Faculty of Medicine, Ankara, Turkey.
3
Department of Neonatology, Etlik Zubeyde Hanim Women's Health Teaching and Research Hospital, University of Health Sciences, Ankara, Turkey.
4
Neonatology Division, Memorial Hospital, Istanbul, Turkey.
5
Department of Neonatology Dr Zekai Tahir Burak Women's Health Education and Research Hospital, University of Health Sciences, Ankara, Turkey.
6
Department of Neonatology, Zeynep Kamil Maternity and Children's Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
7
Department of Neonatology, Inonu University, Faculty of Medicine, Malatya, Turkey.
8
Department of Neonatology, Necmettin Erbakan University, Meram Faculty of Medicine, Konya, Turkey.
9
Department of Neonatology, Kanuni Sultan Suleyman Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
10
Department of Neonatology, Konya Education and Research Hospital, University of Health Sciences, Konya, Turkey.
11
Neonatology Division, Medicalpark Hospital, Gaziantep, Turkey.
12
Department of Neonatology, Dr Behcet Uz Children's Hospital, University of Health Sciences, Izmir, Turkey.
13
Department of Neonatology, Ataturk University, Faculty of Medicine, Erzurum, Turkey.
14
Department of Neonatology, Medipol University, Faculty of Medicine, Istanbul, Turkey.
15
Department of Neonatology, Cukurova University, Faculty of Medicine, Adana, Turkey.
16
Neonatology Division, Mersin State Hospital, Mersin, Turkey.
17
Department of Neonatology, Erciyes University, Faculty of Medicine, Kayseri, Turkey.
18
Department of Neonatology, Baskent University, Faculty of Medicine, Adana, Turkey.
19
Department of Neonatology, Erzurum Nenehatun Maternity Hospital, Erzurum, Turkey.
20
Neonatology Division, Megapark Hospital, Kahramanmaras, Turkey.
21
Neonatology Division, Denizli State Hospital, Denizli, Turkey.
22
Department of Neonatology, Dr. Faruk Sukan Maternity and Children's Hospital, Konya, Turkey.
23
Department of Neonatology, Yuksek Ihtisas University, Faculty of Medicine, Ankara, Turkey.
24
Department of Neonatology, Ankara University Faculty of Medicine, Ankara, Turkey.
25
Department of Neonatology, Kartal Lutfi Kirdar Education and Research Hospital, University of Health Sciences, Istanbul, Turkey.
26
Neonatology Division, Doruk Private Hospital, Bursa, Turkey.
27
Department of Neonatology, Numune Training and Education Hospital, University of Health Sciences, Adana, Turkey.
28
Department of Neonatology, Sisli Hamidiye Etfal Education and Research Hospital, University of Health Sciences, Istanbul, Turkey.
29
Neonatology Division, NCR International Hospital, Gaziantep, Turkey.
30
Department of Neonatology, Tepecik Training and Research Hospital, University of Health Sciences, Izmir, Turkey.
31
Department of Neonatology, Ondokuz Mayıs University, Faculty of Medicine, Samsun, Turkey.
32
Department of Neonatology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
33
Department of Neonatology, Bulent Ecevit University Faculty of Medicine, Zonguldak, Turkey.
34
Department of Neonatology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
35
Neonatology Division, Denizli Saglik Hospital, Denizli, Turkey.
36
Department of Neonatology, Mustafa Kemal University Faculty of Medicine, Hatay, Turkey.
37
Department of Neonatology, Pamukkale University Faculty of Medicine, Denizli, Turkey.
38
Department of Neonatology, Dr Sami Ulus Maternity and Children's Hospital, University of Health Sciences, Ankara, Turkey.
39
Department of Neonatology, Kahramanmaras Sutcu Imam University, Faculty of Medicine, Kahramanmaras, Turkey.
40
Department of Neonatology, Fırat University, Faculty of Medicine, Elazig, Turkey.
41
Department of Neonatology, Yuzuncu Yil University, Faculty of Medicine, Van, Turkey.
42
Department of Neonatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.
43
Department of Neonatology, Trakya University Faculty of Medicine, Edirne, Turkey.
44
Department of Neonatology, Gaziosmanpasa University, Faculty of Medicine, Tokat, Turkey.
45
Department of Neonatology, Baskent University, Faculty of Medicine, Konya, Turkey.
46
Department of Neonatology, Uludag University, Faculty of Medicine, Bursa, Turkey.
47
Department of Neonatology, Suleymaniye Maternity, Research & Training Hospital, University of Health Sciences, Istanbul, Turkey.
48
Department of Neonatology, Medeniyet University, Faculty of Medicine, Istanbul, Turkey.
49
Department of Neonatology, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey.
50
Department of Neonatology, Bezmialem University, Faculty of Medicine, Istanbul, Turkey.
51
Department of Neonatology, Umraniye Education and Research Hospital, University of Health Sciences, Istanbul, Turkey.
52
Department of Neonatology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey.
53
Department of Neonatology, Osmangazi University Faculty of Medicine, Eskisehir, Turkey.
54
Department of Neonatology, Koc University, Faculty of Medicine, Istanbul, Turkey.
55
Department of Neonatology, Bursa Dortcelik Children's Hospital, Bursa, Turkey.
56
Department of Neonatology, Marmara University, Faculty of Medicine, Istanbul, Turkey.
57
Department of Neonatology, Bagcilar Education and Research Hospital, University of Health Sciences, Istanbul, Turkey.
58
Department of Neonatology, Ege University, Faculty of Medicine, Izmir, Turkey.
59
Department of Neonatology, Acıbadem University, Faculty of Medicine, Istanbul, Turkey.
60
Department of Neonatology, Baskent University, Faculty of Medicine, Ankara, Turkey.
61
Department of Neonatology, Kirikkale University, Faculty of Medicine, Kirikkale, Turkey.
62
Neonatology Division, Medova Hospital, Konya, Turkey.
63
Department of Neonatology, Cengiz Gokcek Maternity and Children's Hospital, Gaziantep, Turkey.
64
Department of Neonatology, Trabzon Kanuni Education and Research Hospital, University of Health Sciences, Trabzon, Turkey.
65
Department of Neonatology, Onsekizmart University, Faculty of Medicine, Canakkale, Turkey.
66
Neonatology Division, Ankara Guven Hospital, Ankara, Turkey.
67
Department of Neonatology, Adnan Menderes University, Faculty of Medicine, Aydin, Turkey.
68
Department of Neonatology, Konya Selcuk University, Faculty of Medicine, Konya, Turkey.
69
Department of Neonatology, Kecioren Education and Research Hospital, University of Health Sciences, Ankara, Turkey.
70
Neonatology Division, Atasehir Kadikoy Sifa Hospital, Istanbul, Turkey.
71
Department of Neonatology, Mugla Sıtkı Kocman University Faculty of Medicine, Mugla, Turkey.

Abstract

OBJECTIVE:

To investigate the early neonatal outcomes of very-low-birth-weight (VLBW) infants discharged home from neonatal intensive care units (NICUs) in Turkey.

MATERIAL AND METHODS:

A prospective cohort study was performed between April 1, 2016 and April 30, 2017. The study included VLBW infants admitted to level III NICUs. Perinatal and neonatal data of all infants born with a birth weight of ≤1500 g were collected for infants who survived.

RESULTS:

Data from 69 NICUs were obtained. The mean birth weight and gestational age were 1137±245 g and 29±2.4 weeks, respectively. During the study period, 78% of VLBW infants survived to discharge and 48% of survived infants had no major neonatal morbidity. VLBW infants who survived were evaluated in terms of major morbidities: bronchopulmonary dysplasia was detected in 23.7% of infants, necrotizing enterocolitis in 9.1%, blood culture proven late-onset sepsis (LOS) in 21.1%, blood culture negative LOS in 21.3%, severe intraventricular hemorrhage in 5.4% and severe retinopathy of prematurity in 11.1%. Hemodynamically significant patent ductus arteriosus was diagnosed in 24.8% of infants. Antenatal steroids were administered to 42.9% of mothers.

CONCLUSION:

The present investigation is the first multicenter study to include epidemiological information on VLBW infants in Turkey. Morbidity rate in VLBW infants is a serious concern and higher than those in developed countries. Implementation of oxygen therapy with appropriate monitoring, better antenatal and neonatal care and control of sepsis may reduce the prevalence of neonatal morbidities. Therefore, monitoring standards of neonatal care and implementing quality improvement projects across the country are essential for improving neonatal outcomes in Turkish NICUs.

Conflict of interest statement

The authors have declared that no competing interests exist.

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