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Endokrynol Pol. 2020;71(1):21-26. doi: 10.5603/EP.a2019.0057. Epub 2019 Dec 18.

Selected adipose tissue hormones in the blood of patients with ischaemic cerebral stroke.

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Department of Neurology with Stroke Ward, Provincial Specialist Hospital, Bełchatów, Poland.
Department of Pathophysiology and Endocrinology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Zabrze, Poland.
Department of Craniomaxillofacial and Oral Surgery, Faculty of Medical Sciences, Medical University of Silesia in Katowice, Katowice, Poland.
Department of Endocrinology and Metabolic Disorders, Provincial Specialist Hospital No. 3, Rybnik, Poland.



Despite considerable progress in knowledge, ischaemic stroke is still a disease that causes serious clinical problems. A role in its pathogenesis can be attributed to i.a. adipose tissue hormones. The aim of this paper is to assess the blood levels of selected adipocytokines in patients during the acute phase of ischaemic stroke as compared to healthy persons, and an attempt to indicate a correlation between their blood concentrations and the level of stroke severity and its outcomes.


The study included 46 patients with fresh ischaemic stroke (27 females, 19 males, average age 67.6 years). All patients had a CT scan of the head, their neurological condition was assessed using a stroke severity scale, and their blood levels of resistin, chemerin, and visfatin were tested. The control group consisted of 32 patients (16 females, 16 males, average age 64.1 years) who had never suffered cerebrovascular diseases.


Elevated levels of both resistin and chemerin were found in the group of patients with ischaemic stroke (9.17 ± 2.95 ng/mL vs. 6.55 ± 2.01 ng/mL for resistin and 265.0 ± 59.3 ng/mL vs. 191.0 ± 43.6 ng/mL for chemerin). It was also found that the blood concentration of chemerin was higher in females than in males with stroke. However, no difference was found in visfatin blood concentration between the group with ischaemic stroke and the control group (1.65 ± 1.09 ng/mL vs. 1.5 ± 1.39 ng/mL).


Higher resistin and chemerin blood concentrations significantly increase the risk of ischaemic stroke. The level of stroke severity at the moment of its occurrence and during its course do not depend on the concentrations of adipocytokines under analysis.


adipocytokines; chemerin; ischaemic stroke; resistin; visfatin

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