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Open Access Maced J Med Sci. 2019 Aug 30;7(18):3101-3105. doi: 10.3889/oamjms.2019.771. eCollection 2019 Sep 30.

The Effects of Magnesium - Melatonin - Vit B Complex Supplementation in Treatment of Insomnia.

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Clinic for Mental Disorders "Dr. Laza Lazarevic", Belgrade, Serbia.
Abela Pharm, Belgrade, Serbia.
Department of Dermatology and Venereology, Military Medical Academy, Belgrade, Serbia.
Military Medical Academy, Belgrade, Serbia.
Clinic for Plastic Surgery and Burns, Military Medical Academy, Belgrade, Serbia.
Department of Dermatology and Allergology, Städtisches Klinikum Dresden, Dresden, Germany.
Guglielmo Marconi University, Rome, Italy.
Vietnam National Hospital of Dermatology and Venereology, Hanoi, Vietnam.
Department of Nuclear Physics, Sub-nuclear and Radiation, G. Marconi University, Rome, Italy.
Department of Dermatology, G. Marconi University, Rome, Italy.


Insomnia means difficulty in falling asleep and/or stays asleep. Insomnia commonly leads to daytime sleepiness, lethargy, and a general feeling of being unwell. The most common treatment of insomnia includes GABAA receptor positive allosteric modulators or Melatonin agonists. Our study aimed to evaluate the efficacy of Magnesium- melatonin-vitamin B complex supplement in the treatment of insomnia. The study included 60 patients diagnosed with insomnia. The patients were randomly divided into study group (N = 30), and control group (N = 30), and study group was treated with Magnesium-melatonin-vitamin B complex (one dose contains 175 mg liposomal magnesium oxide, 10 mg Vit B6, 16 μg vit B12, melatonin 1 mg, Extrafolate-S 600 μg) once a day 1 hour before sleep, during the 3 months. The severity of insomnia symptoms was measured by self-reported Athens insomnia scale (AIS), with a cut-off score by Soldatos (AIS score ≥ 6). Mean AIS score at zero points was 14.93 ± 3.778 in the study group and 14.37 ± 4.081 in the control group (p = 0.476), indicating the compatibility of the groups, and both scores correspond to mild to moderate insomnia. Mean AIS score after 3 months of the Magnesium- melatonin- vitamin B complex supplementation was 10.50 ± 4.21 corresponding to mild insomnia, while median AIS score in the control group was 15.13 ± 3.76 which is referred to moderate insomnia, and difference among groups was significant (p = 0.000). Our founding's indicating that 3 months of the Magnesium- melatonin-vitamin B complex supplementation has a beneficial effect in the treatment of insomnia regardless of cause.


Athens insomnia scale; Insomnia; Magnesium; Melatonin; Supplement

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