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Open Access Maced J Med Sci. 2019 Aug 30;7(18):3101-3105. doi: 10.3889/oamjms.2019.771. eCollection 2019 Sep 30.

The Effects of Magnesium - Melatonin - Vit B Complex Supplementation in Treatment of Insomnia.

Author information

1
Clinic for Mental Disorders "Dr. Laza Lazarevic", Belgrade, Serbia.
2
Abela Pharm, Belgrade, Serbia.
3
Department of Dermatology and Venereology, Military Medical Academy, Belgrade, Serbia.
4
Military Medical Academy, Belgrade, Serbia.
5
Clinic for Plastic Surgery and Burns, Military Medical Academy, Belgrade, Serbia.
6
Department of Dermatology and Allergology, Städtisches Klinikum Dresden, Dresden, Germany.
7
Guglielmo Marconi University, Rome, Italy.
8
Vietnam National Hospital of Dermatology and Venereology, Hanoi, Vietnam.
9
Department of Nuclear Physics, Sub-nuclear and Radiation, G. Marconi University, Rome, Italy.
10
Department of Dermatology, G. Marconi University, Rome, Italy.

Abstract

Insomnia means difficulty in falling asleep and/or stays asleep. Insomnia commonly leads to daytime sleepiness, lethargy, and a general feeling of being unwell. The most common treatment of insomnia includes GABAA receptor positive allosteric modulators or Melatonin agonists. Our study aimed to evaluate the efficacy of Magnesium- melatonin-vitamin B complex supplement in the treatment of insomnia. The study included 60 patients diagnosed with insomnia. The patients were randomly divided into study group (N = 30), and control group (N = 30), and study group was treated with Magnesium-melatonin-vitamin B complex (one dose contains 175 mg liposomal magnesium oxide, 10 mg Vit B6, 16 μg vit B12, melatonin 1 mg, Extrafolate-S 600 μg) once a day 1 hour before sleep, during the 3 months. The severity of insomnia symptoms was measured by self-reported Athens insomnia scale (AIS), with a cut-off score by Soldatos (AIS score ≥ 6). Mean AIS score at zero points was 14.93 ± 3.778 in the study group and 14.37 ± 4.081 in the control group (p = 0.476), indicating the compatibility of the groups, and both scores correspond to mild to moderate insomnia. Mean AIS score after 3 months of the Magnesium- melatonin- vitamin B complex supplementation was 10.50 ± 4.21 corresponding to mild insomnia, while median AIS score in the control group was 15.13 ± 3.76 which is referred to moderate insomnia, and difference among groups was significant (p = 0.000). Our founding's indicating that 3 months of the Magnesium- melatonin-vitamin B complex supplementation has a beneficial effect in the treatment of insomnia regardless of cause.

KEYWORDS:

Athens insomnia scale; Insomnia; Magnesium; Melatonin; Supplement

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