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J Res Med Sci. 2019 Nov 27;24:100. doi: 10.4103/jrms.JRMS_66_19. eCollection 2019.

Effect of a Persian medicine preparation, Ma'aljobon, on constipation in patients with hypertension.

Author information

Department of Persian Medicine, Birjand University of Medical Sciences, Birjand, Iran.
Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran.
School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran.
Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran.
Bu-Ali Hospital, Birjand, Iran.



Constipation is a common and prevalent digestive problem. Forcing and straining due to constipation may have a negative effect on some parts of the body, including the heart. The aim of the study was to evaluate the effect of Ma'aljobon (a kind of whey) on functional constipation in hypertensive patients.

Materials and Methods:

The present double-blind, placebo-controlled randomized clinical trial was a part of the study about the effect of Ma'aljobon on stage 1 hypertension, performed in 2017-2018. Hypertensive patients accompanying constipation were included in the study. Patients were randomly divided into two groups: Group A (n = 19) received 25 g of Ma'aljobon powder and Group B (n = 22) received 25 g of maltodextrin powder, twice a day for 6 weeks. The number and quality of defecation during a day were evaluated at baseline and at the end of the study within and between groups. Data were analyzed by SPSS software (version: 17) using Chi-square or Fisher's exact test. P <0.05 was considered as significant level.


Forty-one patients had inclusion criteria, of whom 34 patients completed the study (19 in Group A and 15 in Group B). The mean ± standard deviation age of patients was 53.86 ± 8.92 years (range: 34-80 years). Before intervention, there was no significant difference between the two groups with respect to constipation; however, after 6 weeks' treatment, the frequency of constipation was significantly different between groups (P < 0.001). At the end of 6th week, constipation in the Group A was improved completely in terms of the number of defecation and stool consistency; but, in the Group B, eight (53.33%) patients still suffered from constipation (P < 0.001). No specific complications were reported in both groups.


Ma'aljobon can improve constipation in hypertensive patients without any adverse effect.


Constipation; Ma'aljobon; Persian medicine; hypertension; whey protein

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