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Eur Heart J. 2019 Dec 18. pii: ehz849. doi: 10.1093/eurheartj/ehz849. [Epub ahead of print]

Sleep patterns, genetic susceptibility, and incident cardiovascular disease: a prospective study of 385 292 UK biobank participants.

Fan M1,2, Sun D1,2, Zhou T1, Heianza Y1, Lv J2,3,4, Li L2, Qi L1,5.

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Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, 1440 Canal Street, Suite 1724, New Orleans, LA 70112, USA.
Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100191, China.
Key Laboratory of Molecular Cardiovascular Sciences (Peking University), Ministry of Education, 38 Xueyuan Road, Beijing 100191, China.
Peking University Institute of Environmental Medicine, 38 Xueyuan Road, Beijing 100191, China.
Department of Nutrition, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA.



To quantify the association of combined sleep behaviours and genetic susceptibility with the incidence of cardiovascular disease (CVD).


This study included 385 292 participants initially free of CVD from UK Biobank. We newly created a healthy sleep score according to five sleep factors and defined the low-risk groups as follows: early chronotype, sleep 7-8 h per day, never/rarely insomnia, no snoring, and no frequent excessive daytime sleepiness. Weighted genetic risk scores of coronary heart disease (CHD) or stroke were calculated. During a median of 8.5 years of follow-up, we documented 7280 incident CVD cases including 4667 CHD and 2650 stroke cases. Compared to those with a sleep score of 0-1, participants with a score of 5 had a 35% (19-48%), 34% (22-44%), and 34% (25-42%) reduced risk of CVD, CHD, and stroke, respectively. Nearly 10% of cardiovascular events in this cohort could be attributed to poor sleep pattern. Participants with poor sleep pattern and high genetic risk showed the highest risk of CHD and stroke.


In this large prospective study, a healthy sleep pattern was associated with reduced risks of CVD, CHD, and stroke among participants with low, intermediate, or high genetic risk.


Cardiovascular disease; Genetic predisposition to disease; Sleep behaviour


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