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Curr Biol. 2019 Dec 16;29(24):R1310-R1312. doi: 10.1016/j.cub.2019.11.012.

Sleep: The Very Long Posited (VLPO) Synaptic Pathways of Arousal.

Author information

1
Department of Fundamental Neurosciences (DNF), University of Lausanne, Rue du Bugnon 9, CH-1005 Lausanne, Switzerland. Electronic address: anita.luthi@unil.ch.

Abstract

Waking up requires excitation of the brain's wake centers. A new study shows that synaptic inhibition of sleep centers also induces wakefulness. This inhibition, driven by lateral hypothalamic GABAergic neurons, may coordinate sleep-wake behavior with stress, motivation and energy balance.

PMID:
31846678
DOI:
10.1016/j.cub.2019.11.012

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