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Med Sci (Paris). 2019 Nov;35(11):871-879. doi: 10.1051/medsci/2019166. Epub 2019 Dec 17.

[Laser microdissection applications in histology: an open way to molecular studies].

[Article in French; Abstract available in French from the publisher]

Author information

Institut de recherche Saint-Louis, Paris, France, UMR_S 976 Inserm, Université de Paris, Hôpital Saint-Louis, 1 avenue Claude-Vellefaux, F-75010 Paris, France.


in English, French

One of the most fascinating aspects of the use of a laser beam in the field of biology has emerged with the development of devices able to perform fine dissections of biological tissues. Laser microdissection can collect phenotypically identical cells from tissue regions laid on a microscope slide in order to make differential molecular analyses on these microdissected cells. Laser microdissection can be used many areas including oncology to specify molecular mechanisms that enable to adapt a treatment related to diagnosis and research in biology, but also forensic science for tissue selection, neurology for post-mortem studies on patients with Alzheimer's disease, for clonality studies from cell cultures and cytogenetics to decipher chromosomal rearrangements. This technology represents the missing link between clinical observations and the intrinsic physiological mechanisms of biological tissues and its major applications will be addressed here.


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