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Med Sci (Paris). 2019 Nov;35(11):859-865. doi: 10.1051/medsci/2019167. Epub 2019 Dec 17.

[Fetal alcohol exposure: when placenta would help to the early diagnosis of child brain impairments].

[Article in French; Abstract available in French from the publisher]

Author information

1
Inserm U1245, Équipe 4, Rouen Université, Normandie Université, Rouen, France.
2
Inserm U1245, Équipe 4, Rouen Université, Normandie Université, Rouen, France - Service de Pathologie, Hôpital Charles-Nicolle, CHU de Rouen, France.
3
Inserm U1245, Équipe 4, Rouen Université, Normandie Université, Rouen, France - Service de Biochimie métabolique, Hôpital Charles-Nicolle, CHU de Rouen, France.
4
Service d'Anatomie pathologique, Hôpital Morvan, CHU de Brest, France.
5
Inserm UMR-S1139, Université Paris Descartes, Sorbonne Paris Cité, Fondation PremUp, Paris, France.
6
Inserm U1245, Équipe 4, Rouen Université, Normandie Université, Rouen, France - Service de Pédiatrie Néonatale et Réanimation, Neuropédiatrie, Camsp, Hôpital Charles-Nicolle, CHU de Rouen, 37 boulevard Gambetta, 76000 Rouen, France.

Abstract

in English, French

Alcohol consumption during pregnancy constitutes a major cause of neurodevelopmental and behavioral disabilities. Whereas it is possible for clinicians to establish a perinatal diagnosis of fetal alcohol syndrome, the more severe expression of fetal alcohol spectrum disorder (FASD), most FASD children are late or mis-diagnosed due to a lack of clear morphological and neurodevelopmental abnormalities. Several precious years of care are consequently lost. Recent data revealed a functional placenta-brain axis involved in the control of the fetal brain angiogenesis which is impaired by in utero alcohol exposure. Because in the developing fetal brain a correct angiogenesis is required for a correct neurodevelopment, these preclinical and clinical advances pave the way for a new generation of placental biomarkers for early diagnosis of FASD.

PMID:
31845877
DOI:
10.1051/medsci/2019167

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