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Med Sci (Paris). 2019 Nov;35(11):852-858. doi: 10.1051/medsci/2019172. Epub 2019 Dec 17.

[Autophagy and spermatozoa].

[Article in French; Abstract available in French from the publisher]

Author information

1
CHU de Rennes, Département de Gynécologie-Obstétrique et Reproduction Humaine-CECOS, Hôpital Sud, 16 boulevard de Bulgarie, 35000 Rennes, France.
2
CHU de Rennes, Département de Gynécologie-Obstétrique et Reproduction Humaine-CECOS, Hôpital Sud, 16 boulevard de Bulgarie, 35000 Rennes, France - Académie des Sciences, Institut Sechenov, Saint-Pétersbourg, Russie.
3
Laboratoire Signalisation et Transports Ioniques Membranaires (STIM), CNRS 7368, 1 rue Georges Bonnet, 86022 Poitiers Cedex, France.
4
Plateforme H2P2, 2 avenue du Pr Léon Bernard, CS 24317, 35043 Rennes Cedex, France.
5
Plateforme MRic (Microscopy Rennes Imaging center), BIOSIT, 2 avenue du Pr Léon Bernard, 35 000 Rennes, France.
6
Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, 35000 Rennes, France.
7
CHU de Rennes, Département de Gynécologie-Obstétrique et Reproduction Humaine-CECOS, Hôpital Sud, 16 boulevard de Bulgarie, 35000 Rennes, France - Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, 35000 Rennes, France.

Abstract

in English, French

Spermiogenesis, the ultimate stage of spermatogenesis, is a process involving autophagy. At this stage, the acrosome is generated by vesicular fusion and most of the cytoplasm disappears. Autophagy, literally "eating oneself", allowing the elimination and replacement of proteins and nonfunctional organelles, ensures the recycling of cellular constituents and is a highly conserved cellular mechanism within eukaryotic cells. The machinery of autophagy is present in the spermatozoon, regulating the vitality and mobility of the cells. The environmental and behavioral impact on autophagy and the consequences on spermatogenesis are beginning to be studied. The purpose of this review is to synthesize current knowledge about autophagy in the mature male gamete.

PMID:
31845876
DOI:
10.1051/medsci/2019172

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