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Pediatr Obes. 2020 Mar;15(3):e12587. doi: 10.1111/ijpo.12587. Epub 2019 Dec 16.

An examination of sex differences in associations between cord blood adipokines and childhood adiposity.

Author information

1
Perinatal Epidemiology Research Unit, Dalhousie University, Halifax, Canada.
2
Population Studies Division, Health Canada, Ottawa, Canada.
3
School of Public Health, University of Michigan, Michigan (MI), Ann Arbor, USA.
4
Obstetrics and Gynecology, University of Sherbrooke, Sherbrooke, Canada.
5
School of Psychology, Universite Laval, Quebec City, Canada.
6
Obstetrics and Gynecology, McGill University, Montreal, Canada.

Abstract

BACKGROUND:

Though the physiological roles of adipokines in metabolism, insulin resistance and satiety are clear, literature regarding associations between cord blood adipokine levels and childhood adiposity is equivocal.

OBJECTIVES:

To determine whether cord blood levels of leptin and adiponectin are associated with adiposity in children 2 to 5 years of age, and whether such associations are modified by sex.

METHODS:

Leptin and adiponectin levels were measured in cord blood and anthropometric measures were completed on 550 children enrolled in the Maternal-Infant Research on Environmental Chemicals Child Development Plus study (MIREC-CD Plus). We used multivariable linear and Poisson regression models to determine associations between cord blood adipokine levels and child body mass index (BMI), triceps and subscapular skinfold thickness and risk of overweight/obesity and to assess effect modification by child sex.

RESULTS:

Cord blood adiponectin was significantly associated with modest increases in BMI and the sum of triceps and subscapular skinfold z-scores in boys but not girls. A doubling of adiponectin levels was associated with a 30% increased risk of overweight/obesity in boys (RR = 1.30; 95% CI: 1.02, 1.64). Leptin was not associated with anthropometric measures in either sex.

CONCLUSIONS:

The observed associations between adiponectin and adiposity in boys were statistically significant, of moderate magnitude, and underscore the value of considering sex-specific patterns.

KEYWORDS:

body mass index; childhood obesity; cord blood adipokines; skinfold

PMID:
31845502
DOI:
10.1111/ijpo.12587

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