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BMC Med Genet. 2019 Dec 16;20(1):197. doi: 10.1186/s12881-019-0931-7.

LRCH1 polymorphisms linked to delayed encephalopathy after acute carbon monoxide poisoning identified by GWAS analysis followed by Sequenom MassARRAY® validation.

Author information

1
Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, No. 388 Jianshe Middle Road, Muye District, Xinxiang City, 453002, Henan Province, China.
2
Qinyang People's Hospital, Jiaozuo City, 454550, Henan Province, China.
3
The Psychology College of Xinxiang Medical University, Xinxiang City, 453002, Henan Province, China.
4
International Joint Research Laboratory for Psychiatry and Neuroscience of Henan, Henan Key Lab of Biological Psychiatry of Xinxiang Medical University, Xinxiang City, 453002, Henan Province, China. lwq781603@163.com.
5
Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, No. 388 Jianshe Middle Road, Muye District, Xinxiang City, 453002, Henan Province, China. gurenjun1961@163.com.

Abstract

BACKGROUND:

We explored the association of leucine-rich repeats and calponin homology domain containing 1 (LRCH1) gene polymorphisms with genetic susceptibility to delayed encephalopathy after acute carbon monoxide poisoning (DEACMP), which might provide a theoretical basis for the pathogenesis, diagnosis, and prognosis research of DEACMP.

METHODS:

Four single nucleotide polymorphisms, rs1539177 (G/A), rs17068697 (G/A), rs9534475 (A/C), and rs2236592 (T/C), of LRCH1, selected as candidate genes through genome-wide association analysis, were genotyped in 661 patients (DEACMP group: 235 cases; ACMP group: 426 cases) using Sequenom Massarray®. The association analysis of four SNPs and LRCH1 was performed under different genetic models.

RESULTS:

LRCH1 polymorphisms (rs1539177, rs17068697, rs9534475) under additive and dominant genetic models were significantly associated with an increased risk of DEACMP, but no significant association under allele and recessive models was found. The LRCH1 rs2236592 polymorphism was susceptible to DEACMP only under the dominant model (TT/TC + CC, OR = 1.616, 95% CI: 1.092-2.390, P = 0.015784). In addition, the A allele gene of rs9534475 polymorphism in LRCH1 might increase the risk for DEACMP (OR = 1.273, 95% CI: 1.013-1.601, P = 0.038445).

CONCLUSIONS:

We found a significant association between the four LRCH1 polymorphisms and DEACMP. The allelic A of rs9534475 polymorphism in LRCH1 might be a risk factor for DEACMP.

KEYWORDS:

ACMP; DEACMP; Genetic model; LRCH1 polymorphisms; SNP genotyping

PMID:
31842790
PMCID:
PMC6916040
DOI:
10.1186/s12881-019-0931-7
[Indexed for MEDLINE]
Free PMC Article

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