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Acta Vet Hung. 2019 Dec;67(4):489-498. doi: 10.1556/004.2019.048.

Antimicrobial susceptibility of Pasteurella multocida isolated from sheep and pigs in Spain - Short communication.

Author information

1
Animal Health Department, Veterinary School, Universidad Complutense de Madrid, Av. Puerta de Hierro, s/n, 28040 Madrid, Spain.
2
Centro de Vigilancia Sanitaria Veterinaria (VISAVET), Universidad Complutense, Madrid, Spain.
3
London School of Hygiene and Tropical Medicine/Royal Veterinary College, University of London, London, United Kingdom.

Abstract

Pasteurella multocida is responsible for economically important diseases in sheep and pigs. Antimicrobial susceptibility studies are essential for initiating rational and effective empirical therapy of P. multocida infections. In this study we investigated the antimicrobial susceptibility to 18 antimicrobial agents of 156 clinical isolates of P. multocida from sheep (n = 87) and pigs (n = 69) using the microdilution method. Both sheep and pig isolates exhibited low levels of resistance (≤ 15%) to ceftiofur, gentamicin, neomycin, spectinomycin, chlortetracycline, tulathromycin, florfenicol, danofloxacin, and enrofloxacin and trimethoprim/sulphamethoxazole, high resistance rates (> 15% up to 50%) to oxytetracycline, tilmicosin, and tiamulin, and very high resistance rates (> 50%) to tylosin tartrate, clindamycin, and sulphadimethoxine. However, sheep isolates exhibited significantly lower percentages of resistance and lower MIC90 values (P < 0.05) than pig isolates for most of the antimicrobials tested. In addition, sheep isolates exhibited also significantly lower phenotypic antimicrobial resistance diversity (8 resistotypes vs. 30 resistotypes). LAC-LIN-SUL-MAC was the resistotype most frequently detected in sheep (39.1%) and LIN-SUL-MAC in pig isolates (26.1%). The differences in susceptibility patterns could be influenced by the lower use of antimicrobials in the small ruminant industry compared with the pig farming industry.

KEYWORDS:

Antimicrobial resistance; Pasteurella multocida; pigs; production system; sheep

PMID:
31842595
DOI:
10.1556/004.2019.048

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