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BMC Med. 2019 Dec 14;17(1):229. doi: 10.1186/s12916-019-1458-7.

Delirium is prevalent in older hospital inpatients and associated with adverse outcomes: results of a prospective multi-centre study on World Delirium Awareness Day.

Collaborators (261)

Welch C, McCluskey L, Wilson D, Chapman GE, Jackson TA, Treml J, Davis D, Cunningham E, Copeland C, Quinn T, Pinkney T, Mahida R, Nightingale P, Richardson S, Todd O, Willott R, Torsney K, Ni Lochlainn M, Giridharan K, Cox N, Masoli J, Ronan L, Gaunt V, Jelley B, Taylor J, Healy R, Rose E, Parkinson M, Macharouthu A, McKenzie E, McCormack R, Hart J, McCulloch A, Henderson N, Beveridge L, Elliott E, Drozdowska B, Taylor-Rowan M, Christodoulides N, Allen J, Brown H, Champion J, Patel R, Hodhody G, Mayor K, Miller CJ, Studley M, Prasad V, Mumtaz E, Cohen S, Abdelbadiee S, Lewis A, Khizar B, Pendleton H, Harkin T, Rutter S, Behbahani A, Behbahani A, Tencheva A, King R, Jones L, Hornsby A, Horton R, Foster K, Moore K, McCormack V, Kearney M, Fisken E, Durcan R, Deacon E, Noble J, Annamalai A, Taranu R, Sen M, Mithrakumar P, Briggs L, Bhatti J, Bhakta S, Achara A, Ellis E, Koshedo S, Aamir A, Wu E, Khalid AB, Visvaratnam P, Obi I, Nashed N, Iwu C, Gurung S, Nagumantry S, Akintade O, Page V, Debrah K, Ball K, Ahmed J, Bei ZX, McClelland SB, Haley M, Pang N, Le Poideven A, Moore E, Cooper F, Grundmann N, Lonsdale-Eccles E, Valentine J, Stratton E, Bowen E, Thake M, Kuek D, Pyc W, Scott D, Rickard F, Gaskell N, McDonald H, Gaunt V, Mills S, Winearls S, A-Odame P, Barlow C, Nicholls I, Norman E, Kirrane K, Jackson P, Chourot C, Beeley LJ, Kay A, Clayton V, Marshall J, Morgan H, Naish G, Hunt C, Mishra R, Bhattacharya S, Rai N, Alareed A, Anderson C, Bhat G, Darko S, Vila De Mucha P, Saliu D, Beharry K, Caines L, Bremakumar S, Furmedge D, Bultynck C, Hindley E, Seymour E, Thayabaran D, Doherty C, Frewen J, Abiola OO, Tetlow S, Tinson G, Morrow O, Greaves I, Bygate R, Yunus A, Bryant C, Jones H, Bowden H, Laud R, Austin K, Bahsoon F, Glasser M, Cheah KL, Speed J, Porter L, Dove J, Hoffman K, Evans O, Nandra T, Giet L, Stapley S, Bargaoanu I, Kadir I, McClean A, Mishra P, Houldershaw K, Andrusca A, Abu E, Swietoslawski A, Ahmed B, Ansell M, Abdullah S, Iqbal S, Wilcockson J, Kabia A, Velusamy K, Syed N, Chuter C, Ahmed H, Ahmad S, Ofoche G, Ibanichuka J, Wheeler A, Chilton A, Hussain Z, Tan F, Quinn S, Croft P, Walker A, Bell C, Wilkes C, Griffiths E, Reid J, Abras A, Adam M, Mohammedseid-Nurhussien A, Shakeel S, Amin Z, Layton GR, Ingamells N, Taylor J, Wynne L, Ikhwan WIC, Waraich H, Cooper O, Thomas P, Williamson E, Naqvi H, Lee H, Holmes E, Offer M, McQuillan A, Jay E, Currie H, Janagal S, Kumbun G, Jenkin R, Jacques H, Gaywood J, Babb L, San MSS, Porter-Bent S, Wilson D, Vedutla T, Nneamaka A, Cheema A, Moorey H, Khan A, Majid Z, Jatti P, Gupta A, Lee T, Chamberlain H, Hughes C, Giles A, Critchlow T, Morgan B, Moseley A, Fennelly G, Pettler S, Bilton E, Astaire E, McKeown W, Williamson K, Rice C, Ramakrishna S, Subhan Z, Haddad N, Krishan A.

Abstract

BACKGROUND:

Delirium is a common severe neuropsychiatric condition secondary to physical illness, which predominantly affects older adults in hospital. Prior to this study, the UK point prevalence of delirium was unknown. We set out to ascertain the point prevalence of delirium across UK hospitals and how this relates to adverse outcomes.

METHODS:

We conducted a prospective observational study across 45 UK acute care hospitals. Older adults aged 65 years and older were screened and assessed for evidence of delirium on World Delirium Awareness Day (14th March 2018). We included patients admitted within the previous 48 h, excluding critical care admissions.

RESULTS:

The point prevalence of Diagnostic and Statistical Manual on Mental Disorders, Fifth Edition (DSM-5) delirium diagnosis was 14.7% (222/1507). Delirium presence was associated with higher Clinical Frailty Scale (CFS): CFS 4-6 (frail) (OR 4.80, CI 2.63-8.74), 7-9 (very frail) (OR 9.33, CI 4.79-18.17), compared to 1-3 (fit). However, higher CFS was associated with reduced delirium recognition (7-9 compared to 1-3; OR 0.16, CI 0.04-0.77). In multivariable analyses, delirium was associated with increased length of stay (+ 3.45 days, CI 1.75-5.07) and increased mortality (OR 2.43, CI 1.44-4.09) at 1 month. Screening for delirium was associated with an increased chance of recognition (OR 5.47, CI 2.67-11.21).

CONCLUSIONS:

Delirium is prevalent in older adults in UK hospitals but remains under-recognised. Frailty is strongly associated with the development of delirium, but delirium is less likely to be recognised in frail patients. The presence of delirium is associated with increased mortality and length of stay at one month. A national programme to increase screening has the potential to improve recognition.

KEYWORDS:

Collaboration; Delirium; Frailty; Older adults

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