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Muscle Nerve. 2019 Dec 14. doi: 10.1002/mus.26783. [Epub ahead of print]

Nutritional neuropathies.

Author information

1
Virginia Commonwealth University, Richmond, Virginia.
2
University of Virginia, Charlottesville, Virginia.

Abstract

Neuropathies associated with nutritional deficiencies are routinely encountered by the practicing neurologist. Although these neuropathies assume different patterns, most are length-dependent, sensory axonopathies. Cobalamin deficiency neuropathy is the exception, often presenting with a non-length-dependent sensory neuropathy. Patients with cobalamin and copper deficiency neuropathy characteristically have concomitant myelopathy, whereas vitamin E deficiency is uniquely associated with a spinocerebellar syndrome. In contrast to those nutrients for which deficiencies produce neuropathies, pyridoxine toxicity results in a non-length-dependent sensory neuronopathy. Deficiencies occur in the context of malnutrition, malabsorption, increased nutrient loss (such as with dialysis), autoimmune conditions such as pernicious anemia, and with certain drugs that inhibit nutrient absorption. When promptly identified, therapeutic nutrient supplementation may result in stabilization or improvement of these neuropathies.

KEYWORDS:

bariatric surgery; deficiency; neuropathy; nutrient; vitamin

PMID:
31837157
DOI:
10.1002/mus.26783

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