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Gastroenterology. 2019 Dec 10. pii: S0016-5085(19)41901-X. doi: 10.1053/j.gastro.2019.11.299. [Epub ahead of print]

Combating gastric cancer in Alaska Native people: An expert and community symposium: Alaska Native Gastric Cancer Symposium.

Author information

1
Arctic Investigations Program, Division of Preparedness and Emerging Infections, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention. Electronic address: xdf8@cdc.gov.
2
Alaska Native Tribal Health Consortium, Anchorage; University of Washington, Seattle, WA.
3
Departments of Medicine and of Epidemiology and Population Health, Stanford University, Stanford, CA.
4
Arctic Investigations Program, Division of Preparedness and Emerging Infections, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention.
5
University of Alaska Anchorage, Anchorage, AK.
6
Alaska Native Tribal Health Consortium, Anchorage.
7
Arctic Investigations Program, Division of Preparedness and Emerging Infections, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention; Alaska Native Tribal Health Consortium, Anchorage.
8
University of Alberta, Edmonton, Alberta, Canada.
9
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.
10
Columbia University, New York, NY.
11
Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
12
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.
13
Seoul National University Hospital, Seoul, Korea.
14
Division of Preparedness and Emerging Infections, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA.
15
Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Albuquerque, New Mexico.

Abstract

Alaska Native (AN) people experience higher incidence of, and mortality from, gastric cancer compared to other U.S. populations1, 2. Compared to the general U.S. population, gastric cancer in AN people occurs at a younger age, is diagnosed at later stages, is more evenly distributed between the sexes, and is more frequently signet-ring or diffuse histology3. It is known that the prevalence of Helicobacter pylori (Hp) infection, a risk factor for gastric cancer, is high in AN people4; however, high antimicrobial resistance combined with high reinfection rates in Alaska make treatment at the population level complex5. In addition, health issues in AN people are uniquely challenging due to the extremely remote locations of many residents. A multiagency workgroup hosted a symposium in Anchorage that brought internationally-recognized experts and local leaders together to evaluate issues around gastric cancer in the AN population. The overall goal of this symposium was to identify the best strategies to combat gastric cancer in the AN population through prevention and early diagnosis.

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