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Bioengineered. 2020 Dec;11(1):11-18. doi: 10.1080/21655979.2019.1704535.

LINC00528 regulates myocardial infarction by targeting the miR-143-3p/COX-2 axis.

Author information

1
Department of Cardiology III, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang, China.
2
Department of Cardiology I, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang, China.
3
Department of Gastroenterology I, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang, China.

Abstract

This study is aimed to explore the roles of LINC00528 in myocardial infarction (MI) progression. Quantitative real-time PCR showed that the expression of LINC00528 and COX-2 was upregulated while miR-143-3p expression was down-regulated in post-MI cells. In function assays, LINC00528 suppression promoted post-MI cells proliferation and reduced cell apoptosis in vitro. In mechanism, LINC00528 interacted with miR-143-3p in post-MI cells. COX-2 served as a target of miR-143-3p in post-MI cells. Besides, LINC00528 inhibition on COX-2 expression and post-MI cells progression could be partially abolished by miR-143-3p inhibitors. Therefore, our findings suggested that LINC00528 exerted its regulatory roles in MI via the miR-143-3p/COX-2 axis, which provided a potential therapeutic target for MI patients treatment.

KEYWORDS:

COX-2; LINC00528; Myocardial infarction; miR-143-3p

PMID:
31833800
PMCID:
PMC6961595
[Available on 2020-12-27]
DOI:
10.1080/21655979.2019.1704535

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