Format

Send to

Choose Destination
J Eur Acad Dermatol Venereol. 2019 Dec;33 Suppl 8:6-10. doi: 10.1111/jdv.15967.

Incidence and mortality for cutaneous squamous cell carcinoma: comparison across three continents.

Author information

1
Center of Clinical Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, University Hospital Essen, Essen, Germany.
2
Department of Epidemiology, School of Public Health, Boston University, Boston, MA, USA.
3
Cancer Registry of North Rhine-Westphalia, Bochum, Germany.
4
QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.
5
Population Health Department, Mohs and Dermatologic Surgery Center, Brigham and Women's Faulkner Hospital, Boston, MA, USA.
6
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
7
CRUK Manchester Institute and Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK.

Abstract

BACKGROUND:

Population-based incidence and mortality studies of cutaneous squamous cell carcinoma (SCC) have been few owing to the commonness of the disease, and rare deaths making accurate mortality statistics difficult.

OBJECTIVES:

Our aim was to summarize SCC incidence and mortality in populations across three continents, exemplified by Australia, the United States (US) and Germany.

METHODS:

We estimated age-specific and age-standardized (Australian Standard 2001 Population) incidence and mortality rates per 100 000 person-years.

RESULTS:

Squamous cell carcinoma incidence is plateauing or falling in Australia, stable in the United States (2013-2015) and rising in Germany (2007-2015). Current incidence estimates in men and women are 341 and 209, 497 and 296, and 54 and 26, respectively, for the three countries. Incidence increases strongly with age in all countries. Mortality of non-melanoma skin cancer appears to be increasing in Germany and stable in Australia (unavailable for the US population).

CONCLUSIONS:

Squamous cell carcinoma is an important health issue, particularly among older men, with incidence exceeding most other cancers. More precise and uniform population-based studies of incidence and mortality are needed to better quantify the impact of SCC on healthcare systems worldwide and to gauge the effect of new treatments such as anti-PD1 therapy on mortality.

PMID:
31833607
PMCID:
PMC6913879
[Available on 2020-12-01]
DOI:
10.1111/jdv.15967

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center