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Genes Dis. 2019 Oct 19;6(4):333-334. doi: 10.1016/j.gendis.2019.10.005. eCollection 2019 Dec.

Oncometabolite modification of Keap1 links GSTZ1 deficiency with cancer.

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Department of Biochemistry, Markey Cancer Center, University of Kentucky College of Medicine, Lexington, KY, 40536, USA.


Metabolic abnormalities are emerging as an active driver to the development, progression and metastasis of various tumors. In the recent issue of the EMBO Journal, Yang and colleagues identified that succinylacetone (SA) could act as an oncometabolite and that accumulation of SA activates the NRF2/IGF1R axis in hepatocellular carcinoma (HCC) development. These discoveries not only yield great insights in the understanding of tumor biology, but also hold significant clinical ramifications, as these findings may pave a new way for the early diagnosis and treatment of HCC.

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