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Bioinformation. 2019 Oct 31;15(10):735-743. doi: 10.6026/97320630015735. eCollection 2019.

Linking Helicobacter pylori with gallbladder and biliary tract cancer in Moroccan population using clinical and pathological profiles.

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Department of Pathology, ARRAZI Hospital, Biopathology Laboratory-Clinical Research Center, Mohammed VI University Hospital, Marrakech, Morocco.
Laboratory of Biochemistry, Environment, and Agrifood, Faculty of Sciences and Techniques-Mohammedia, Hassan II University, Morocco/URAC-36.
Department of Gynecology, Charite University Medicine, Campus Virchow, Augustenburger Platz 1, 13353 Berlin, Germany.


It is of interest to assess the clinical and pathological aspects of Gallbladder and biliary tract carcinomas confirmed by histological data. It is also of further interest to evaluate the link between Helicobacter pylori and biliary tract cancers. Eighty-nine (89) cases (mean age 60±12 years) of Gallbladder and biliary tract cancer confirmed by histological data were enrolled for the study at the Department of Pathology in Mohammed VI University Hospital, in Morocco. The data such as age, sex, clinical and histo pathological features were collected. Bile duct specimens were investigated for H. pylori using Giemsa and immuno histo chemistry staining. Results show that bile duct stones were found in 53.9% of cases. It is known using histological data that adeno carcinoma is common accounting for 70 % of all bile duct tumors. Moreover, Helicobacter pylori was detected in 54% of cases linking with the presence of bile duct stones characterized by the histological subtype, the macroscopic classification and lymph node's presence (p<0.001). Thus, data collected suggest the potential association of Helicobacter pylori with gallbladder cancer possibly through the formation of bile duct stones.


Biliary duct malignancies; Morocco; gallbladder malignancies; histo pathological profile

Conflict of interest statement

The authors have no conflict of interest to disclose.

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