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Indian J Pharmacol. 2019 Sep-Oct;51(5):330-336. doi: 10.4103/ijp.IJP_217_18. Epub 2019 Nov 26.

Effect of a polyherbal formulation in streptozotocin-induced diabetic nephropathy in wistar rats.

Author information

1
Department of Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research (RIPER), Anantapuramu, Andhra Pradesh, India.
2
Department of Pharmaceutics, Raghavendra Institute of Pharmaceutical Education and Research (RIPER), Anantapuramu, Andhra Pradesh, India.

Abstract

OBJECTIVES:

Chronic kidney failure among people with diabetes mellitus (DM) is a burgeoning health problem that affects up to 25% of patients with type 2 DM. Current pharmacological treatment for diabetic nephropathy (DN) does not stop the attainment of renal complications. The intention of the current study was to explore the role of a polyherbal formulation (PHF) in diabetic-induced nephropathy in experimental animals.

MATERIALS AND METHODS:

Diabetic rats were grouped as follows and underwent the following treatment for about 16 weeks: Group I - normal rats - no treatment, Group II - DN rats - only vehicle (p.o), and Group III and IV - DN rats - PHF orally at 250 and 500 mg/kg, respectively. After the treatment, the animals were sacrificed, and lipid, renal function, and inflammatory markers were estimated. The observed microscopic changes in kidney were analyzed.

RESULTS:

Animals administered with PHF exhibited noteworthy decrease in triglycerides, total cholesterol, very low-density lipoprotein (LDL), LDL, serum creatinine, urinary protein, urinary albumin excretion rate, advanced glycation end products, type IV collagen excretion, interleukin-6, transforming growth factor-ß, and tumor necrosis factor-alpha and showed significant increase in high-density lipoprotein, urine volume, urinary urea, and urine creatinine. Histopathological examination established that administration of PHF prohibited kidney damage.

CONCLUSION:

Treatment with PHF showed beneficial effect on DN which may be due to the improvement of renal function parameters and hyperlipidemic and inflammatory mediators.

KEYWORDS:

Advanced glycation end products; diabetic nephropathy; polyherbal formulation; streptozotocin

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