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Curr Stem Cell Res Ther. 2019 Dec 12. doi: 10.2174/1574888X14666191212160757. [Epub ahead of print]

Will tissue-engineering strategies bring new hope for the reconstruction of nasal septal cartilage?.

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ENT and Head & Neck Research Centre and Skull Base Research Centre, The Five Senses Institute, Hazrat Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran. Iran.
Department of Biomedical Engineering, Faculty of Chemical Engineering, Tarbiat Modares University, Tehran. Iran.
Faculty of Biomedical Engineering, Amirkabir University of Technology, Tehran. Iran.
Nanotechnology and Regenerative Medicine Commercialisation Centre (NanoRegMed Ltd) The London BioScience Innovation Centre, London. United Kingdom.


The nasal septal cartilage plays an important role during the growth of midface and as a vertical strut preventing the collapse of the nasal bones. The repair of nasal cartilage defects remains a major challenge in reconstructive surgery. The tissue engineering strategy in the development of tissue has opened a new perspective to generate functional tissue for transplantation. Given the poor regenerative properties of cartilage and a limited amount of autologous cartilage availability, intense interest has evoked for tissue engineering approaches for cartilage development to provide better outcomes for patients who require nasal septal reconstruction. Despite numerous attempts to substitute the shapely hyaline cartilage in the nasal cartilages, many significant challenges remained unanswered. The aim of this research was critical review the literature on research work carried out on the development of septal cartilage using tissue engineering approach, concerning different cell sources, scaffolds and growth factors, as well as its clinical pathway and trials already carried out.


biomaterial ; biomaterialsurgery; nasal; stem cells; surgery; tissue engineering

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