Format

Send to

Choose Destination
Aging Ment Health. 2019 Dec 12:1-8. doi: 10.1080/13607863.2019.1699021. [Epub ahead of print]

Is dynapenia associated with the onset and persistence of depressive and anxiety symptoms among older adults? Findings from the Irish longitudinal study on ageing.

Carvalho AF1,2, Maes M3,4, Solmi M5,6, Brunoni AR7,8,9, Lange S10, Husain MI1,2, Kurdyak P2,10,11,12, Rehm J2,10,11,13,14,15, Koyanagi A16,17.

Author information

1
Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.
2
Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
3
IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, Australia.
4
Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
5
Department of Neurosciences, University of Padova, Padova, Italy.
6
Padova Neuroscience Center, University of Padova, Padova, Italy.
7
Service of Interdisciplinary Neuromodulation, Laboratory of Neurosciences (LIM-27), Institute of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil.
8
National Institute of Biomarkers in Neuropsychiatry (INBioN), Institute of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil.
9
Department of Clinical Medicine, University Hospital, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
10
Centre for Addiction and Mental Health, Institute for Mental Health Policy Research, Toronto, ON, Canada.
11
Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.
12
Institute for Clinical Evaluative Sciences, Toronto, ON, Canada.
13
Institute of Medical Science, University of Toronto, Faculty of Medicine, Medical Sciences Building, 1 King's College Circle, Toronto, ON, Canada.
14
Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
15
Institute of Clinical Psychology and Psychotherapy & Center of Clinical Epidemiology and Longitudinal Studies, Technische Universität Dresden, Dresden, Germany.
16
Research and Development Unit, Parc Sanitari Sant Joan de Déu, CIBERSAM, Barcelona, Spain.
17
ICREA, Barcelona, Spain.

Abstract

Objectives: The aim of the current study was to assess the associations between dynapenia and the onset and persistence of depression and anxiety among older adults.Methods: This prospective cohort study enrolled community-living older adults (N = 5271; 51.1% females) aged ≥ 50 years (mean age = 63.2, standard deviation = 9.0) from The Irish Longitudinal Study on Aging (TILDA), Ireland. At baseline, participants completed a handgrip assessment. Depression was defined by a score ≥ 16 in the Center of Epidemiology Studies Depression (CES-D) tool and anxiety was considered when participants scored ≥ 8 on the anxiety section of the Hospital Anxiety and Depression Scale (HADS). Outcomes were incident and persistent depression and anxiety at two years follow-up. Multivariable logistic regression models were built for each outcome.Results: After controlling for age, sex, education, marital status, employment status, smoking, body mass index, number of chronic conditions, physical activity, and cognitive function, low handgrip strength indicative of dyapenia (< 30 Kg for men and < 20 Kg for women) was associated with a greater likelihood for incident depressive (OR = 1.44; 95%CI: 1.08-1.92) as well as for persistent depressive (OR = 1.61; 95% CI: 1.01-2.58) and anxiety (OR = 1.61; 95% CI: 1.20-2.14) symptoms.Conclusions: Dynapenia was associated with a higher odds of developing depressive symptoms as well as a greater likelihood to persistent depressive and anxiety symptoms among older adults. Our data suggest that interventions targeting muscle strength may prevent the onset of late-life depression and also may hold promise as novel therapeutic opportunities for depression and anxiety in later life.

KEYWORDS:

Elderly; anxiety; depression; handgrip strength; prospective; psychiatry; sarcopenia

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center