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Curr Diab Rep. 2019 Dec 11;19(12):160. doi: 10.1007/s11892-019-1261-z.

Organoids from the Human Fetal and Adult Pancreas.

Author information

1
Department of Internal Medicine, Nephrology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.
2
Hubrecht Institute for Developmental Biology and Stem Cell Research, Utrecht, The Netherlands.
3
Department of Internal Medicine, Nephrology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands. e.dekoning@lumc.nl.
4
Hubrecht Institute for Developmental Biology and Stem Cell Research, Utrecht, The Netherlands. e.dekoning@lumc.nl.

Abstract

PURPOSE OF REVIEW:

Novel 3D organoid culture techniques have enabled long-term expansion of pancreatic tissue. This review comprehensively summarizes and evaluates the applications of primary tissue-derived pancreatic organoids in regenerative studies, disease modelling, and personalized medicine.

RECENT FINDINGS:

Organoids derived from human fetal and adult pancreatic tissue have been used to study pancreas development and repair. Generated adult human pancreatic organoids harbor the capacity for clonal expansion and endocrine cell formation. In addition, organoids have been generated from human pancreatic ductal adenocarcinoma in order to study tumor behavior and assess drug responses. Pancreatic organoids constitute an important translational bridge between in vitro and in vivo models, enhancing our understanding of pancreatic cell biology. Current applications for pancreatic organoid technology include studies on tissue regeneration, disease modelling, and drug screening.

KEYWORDS:

3D culture; Development; Diabetes Mellitus, Type 1; Organoids; Pancreas; Regeneration; Stem cells

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