Hepatic spheroids derived from human induced pluripotent stem cells in bio-artificial liver rescue porcine acute liver failure

Sitong Chen; Jinglin Wang; Haozhen Ren; Yinan Liu; Chengang Xiang; Cheng Li; Shichun Lu; Yan Shi; Hongkui Deng; Xiaolei Shi

doi:10.1038/s41422-019-0261-5

Hepatic spheroids derived from human induced pluripotent stem cells in bio-artificial liver rescue porcine acute liver failure

Cell Res. 2020 Jan;30(1):95-97. doi: 10.1038/s41422-019-0261-5. Epub 2019 Dec 11.

Authors

Sitong Chen^#¹, Jinglin Wang^#², Haozhen Ren^#², Yinan Liu¹, Chengang Xiang¹, Cheng Li³, Shichun Lu⁴, Yan Shi⁵, Hongkui Deng⁶, Xiaolei Shi⁷

Affiliations

¹ Department of Cell Biology, School of Basic Medical Sciences, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center and the MOE Key Laboratory of Cell Proliferation and Differentiation, College of Life Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, 100191, China.
² Department of Hepatobiliary Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Hepatobiliary Institute of Nanjing University, Nanjing, Jiangsu, China.
³ Center for Bioinformatics, Peking University, Beijing, 100871, China.
⁴ Department of Hepatobiliary Surgery, Chinese PLA General Hospital, Beijing, 100853, China.
⁵ Department of Cell Biology, School of Basic Medical Sciences, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center and the MOE Key Laboratory of Cell Proliferation and Differentiation, College of Life Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, 100191, China. shiyan@bjmu.edu.cn.
⁶ Department of Cell Biology, School of Basic Medical Sciences, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center and the MOE Key Laboratory of Cell Proliferation and Differentiation, College of Life Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, 100191, China. hongkui_deng@pku.edu.cn.
⁷ Department of Hepatobiliary Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Hepatobiliary Institute of Nanjing University, Nanjing, Jiangsu, China. njsxl2000@163.com.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Bioartificial Organs
Cell Differentiation
Hepatocytes / cytology
Humans
Induced Pluripotent Stem Cells / cytology
Induced Pluripotent Stem Cells / physiology*
Liver / anatomy & histology
Liver Failure, Acute / therapy*
Liver, Artificial*
Spheroids, Cellular
Swine