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J Gastrointestin Liver Dis. 2019 Dec 9;28(4):383-387. doi: 10.15403/jgld-335.

Validation of Peptest™ in Patients with Gastro-Esophageal Reflux Disease and Laryngopharyngeal Reflux Undergoing Impedance Testing.

Author information

1
Section of Gastroenterology, Ege University School of Medicine, Ege Reflux Study Group, Izmir, Turkey. . serhat.bor@ege.edu.tr.
2
Section of Gastroenterology, Ege University School of Medicine, Ege Reflux Study Group, Izmir, Turkey. dogacapan@gmail.com.
3
Section of Gastroenterology, Ege University School of Medicine, Ege Reflux Study Group, Izmir, Turkey. rukiye.vardar@ege.edu.tr.
4
RD Biomed Limited, Castle Hill Hospital, United Kingdom. andrew.woodcock@rdbiomed.com.
5
RD Biomed Limited, Castle Hill Hospital, United Kingdom. jeanine.fisher@technostics.com.
6
RD Biomed Limited, Castle Hill Hospital, United Kingdom. peter.dettmar@rdbiomed.com.

Abstract

BACKGROUND AND AIMS:

Pepsin in the gastric refluxate is a marker for a prior reflux event and rapid detection might be achieved using the Peptest™, an in vitro diagnostic medical device. The aim of this study was to validate the use of Peptest™ to reliably diagnose reflux in patients with gastro-esophageal reflux disease (GERD) and laryngopharyngeal reflux (LPR) disease diagnosed with multichannel intraluminal impedance/ pHmetry (MII-pH).

METHODS:

20 reflux patients were recruited of whom 10 had classical GERD and 10 had LPR. All patients underwent MII-pH and provided expectorated saliva samples when a MII-pH reflux event was observed, or reflux symptoms were experienced, and all were tested for the presence of pepsin using the Peptest™.

RESULTS:

Pepsin was detected in 31 out of 45 samples (68.9%). At least 1 positive pepsin result was seen in 16 patients (80%) and this was the same, irrespective of the GERD or LPR diagnosis. Peptest™ had a positive predictive value of 69% to detect MII-pH reflux events.

CONCLUSIONS:

Peptest™ is a good first-line diagnostic procedure to use in reflux sufferers to confirm the presence of reflux.

PMID:
31826051
DOI:
10.15403/jgld-335
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